Two novel cyclic hexapeptides from the genetically engineered Actinosynnema pretiosum

Lu Chunhua; Xie Fei; Shan Chuan; Shen Yuemao

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Two novel cyclic hexapeptides from the genetically engineered Actinosynnema pretiosum

机译：两种新的循环六肽来自遗传工程化的actinosynnema pretosum

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Two novel cyclic hexapeptides designated actinosynneptides A (1) and B (2), together with three tryptophan containing diketopiperazines, namely cyclo(L-Trp-L-Trp) (3), cyclo(L-Trp-N-MeL-Trp) (4), and cyclo(N-MeL-Trp-N-MeL-Trp) (5), were isolated from the culture of the genetically engineered strain HGF052::asm18 derived from Actinosynnema pretiosum ATCC31565. Their structures were elucidated on the basis of spectroscopic analyses and single-crystal X-ray diffractions. Compound 1 is the first example of 3-amino-6-hydroxy-2-piperidone-containing cyclic peptides, and 1 and 2 showed moderate cytotoxic activities against HeLa and PC3 cell lines.

机译：指定肌动糖苷酸的两种新型环状己肽A（1）和B（2），以及含有二酮哌嗪的三种色氨酸，即环偶（L-TRP-L-TRP）（3），Cyclo（L-TRP-N-MEL-TRP）（4）和环瘤（N-MEL-TRP-N-MEL-TRP）（5）被分离出从遗传工程菌株HGF052 :: ASM18的培养物中分离出来自ACTINOSYNNEMA PROFISUM ATCC31565的ASM18。在光谱分析和单晶X射线衍射的基础上阐明了它们的结构。化合物1是含3-氨基-6-羟基-2-哌啶酮的环状肽的第一实例，1和2显示针对HeLa和PC3细胞系的中等细胞毒性活性。

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来源
《Applied Microbiology and Biotechnology》 |2017年第6期|共7页
作者
Lu Chunhua; Xie Fei; Shan Chuan; Shen Yuemao;
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作者单位

Shandong Univ Sch Pharmaceut Sci Key Lab Chem Biol Minist Educ Jinan 250012 Shandong Peoples R China;

Shandong Univ Sch Pharmaceut Sci Key Lab Chem Biol Minist Educ Jinan 250012 Shandong Peoples R China;

Shandong Univ Sch Chem &

Chem Engn Jinan 250100 Shandong Peoples R China;

Shandong Univ Sch Pharmaceut Sci Key Lab Chem Biol Minist Educ Jinan 250012 Shandong Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类应用微生物学;生物工程学（生物技术）;
关键词
Actinosynnema pretiosum; Cyclic hexapeptide; Diketopiperazine;

机译：actinosynnema pretosum;循环六肽;二酮哌嗪;

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专利

1. Two novel cyclic hexapeptides from the genetically engineered Actinosynnema pretiosum [J] . Lu Chunhua, Xie Fei, Shan Chuan, Applied Microbiology and Biotechnology . 2017,第6期

机译：两种新的循环六肽来自遗传工程化的actinosynnema pretosum
2. Identification and Engineering of Post‐PKS Modification Bottlenecks for Ansamitocin P‐3 Titer Improvement in Actinosynnema pretiosum subsp. pretiosum ATCC 31280 [J] . Ning Xinjuan, Wang Xinran, Wu Yuanting, Biotechnology Journal: Healthcare,Nutrition,Technology . 2017,第11期

机译：作者：张莹莹，王玮，王玮，王玮，王玮，王玮，王玮，王玮，王玮，王玮，王玮，王玮，王玮 Pretosum ATCC 31280
3. Metabolomic change and pathway profiling reveal enhanced ansamitocin P-3 production in Actinosynnema pretiosum with low organic nitrogen availability in culture medium [J] . Applied Microbiology and Biotechnology . 2020,第8期

机译：代谢物变化和途径分析揭示了Actinosynnema Pretosum中增强的Ansamitocin P-3产生，培养基中有低有机氮可用性
4. Self-assembling Cyclic Hexapeptides for Peptide Nanotube Formation [C] . Asuka Kohchi, Zhe Wu, Daichi Tanaka Japanese peptide symposium . 2011

机译：肽纳米管形成的自组装循环己肽
5. Quality Control and Captive Rearing Genetics of the Biological Control Agent Trichogramma pretiosum. [D] . Gonzalez-Cabrera, Jaime. 2011

机译：生物防治剂赤眼赤眼蜂的质量控制和人工饲养遗传学。
6. The Antitumor Agent Ansamitocin P-3 Binds to Cell Division Protein FtsZ in Actinosynnema pretiosum [O] . Xinran Wang, Rufan Wang, Qianjin Kang, 2020

机译：抗肿瘤药Ansamitocin P-3结合于光放线放线杆菌中的细胞分裂蛋白FtsZ
7. Adsorption Behavior of Linear and Cyclic Genetically Engineered Platinum Binding Peptides [O] . -1

机译：线性和循环遗传工程铂结合肽的吸附行为
8. Evaluation of Terrestrial Microcosms for Detection, Fate, and Survival Analysis of Genetically Engineered Microorganisms and Their Recombinant Genetic Material [R] . Fredrickson, J. K., Seidler, R. J. 1989

机译：用于遗传工程微生物及其重组遗传物质检测，命运和生存分析的陆地微观评估

Two novel cyclic hexapeptides from the genetically engineered Actinosynnema pretiosum

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