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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Inhibitory effect of orally-administered sulfated polysaccharide ascophyllan isolated from ascophyllum nodosum on the growth of sarcoma-180 solid tumor in mice.
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Inhibitory effect of orally-administered sulfated polysaccharide ascophyllan isolated from ascophyllum nodosum on the growth of sarcoma-180 solid tumor in mice.

机译：口腔施用硫酸化多糖的抑制作用从脑脊液中雌激素中分离出的小鼠Sarcoma-180实体瘤生长。

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摘要

We evaluated the antitumor activity of crude extract and ascophyllan prepared from Ascophyllum nodosum in sarcoma-180 solid tumor-bearing mice with continuous intraperitoneal (i.p.) administration at a dose of 50 mg/kg body weight/day or oral administration at a dose of 500 mg/kg body weight/day. Ascophyllan and crude extract administered via the oral route showed greater antitumor effects than via i.p. route, and the tumor sizes in mice treated with ascopyllan and crude extract were reduced by a mean of 68.7±6.8% and 42.4±24.8% by the oral route, and 41.4±16.1% and 13.6±20.6% by i.p. route compared to control mice. Splenic natural killer cell activity in the mice treated with ascophyllan and crude extract by i.p. route was significantly enhanced, while only a slight increase of this activity was observed in orally-treated mice. Furthermore, increase in spleen weight of tumor-bearing mice was slightly suppressed by oral administration of ascophyllan, whereas i.p. administration resulted in further enlargement. Analysis of serum cytokines revealed that oral treatment with ascophyllan resulted in significant increase of tumor necrosis factor-α and interleukin-12 levels. Since ascophyllan showed no direct cytotoxic effect on sarcoma-180 cells, orally-administered ascophyllan is suggested to exhibit its antitumor activity through the activation of the host immune system.
机译：我们评估了在肉瘤-180实体瘤小鼠中，在50mg / kg体重/日或口服给药的剂量为50mg / kg体重/日或口服给药时，在肉瘤-180实体瘤小鼠中抗胰蛋白酶内骨质组织中的抗肿瘤和雌激素的抗肿瘤活性。 mg / kg体重/天。通过口腔途径施用的Quencophyllan和粗提取物的抗肿瘤效果比通过I.P显示出更大的抗肿瘤效果。途径，用蛔虫和粗提取物处理的小鼠中的肿瘤尺寸减少了口腔途径的平均值68.7±6.8％和42.4±24.8％，41.4±16.1％和13.6±20.6％。与对照小鼠相比的途径。用Ascophyllan和原油提取物处理的小鼠中的脾自然杀伤细胞活性通过I.P.途径显着增强，而在口服处理的小鼠中仅观察到该活性的略微增加。此外，通过口服施用胰腺施用肿瘤小鼠的脾脏重量的增加，Ispofophyllan略微抑制，而i.p。管理导致进一步扩大。血清细胞因子的分析显示，患有雌激素的口腔治疗导致肿瘤坏死因子-α和白细胞介素-12水平的显着增加。由于雌激素对Sarcoma-180细胞没有直接细胞毒性作用，因此建议通过激活宿主免疫系统来表现出抗肿瘤活性的口腔施用的雌激素。

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