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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Higher Biologically Effective Dose Predicts Survival in SBRT of Pancreatic Cancer: A Multicentric Analysis (PAULA-1)
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Higher Biologically Effective Dose Predicts Survival in SBRT of Pancreatic Cancer: A Multicentric Analysis (PAULA-1)

机译：更高的生物学有效剂量预测胰腺癌SBRT的存活：多中心分析（Paula-1）

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Aim: The purpose of the present multicentric study was to review stereotactic body radiotherapy (SBRT) with or without chemotherapy (CHT) experience in locally advanced pancreatic cancer (LAPC). Endpoints were overall survival (OS), local control (LC), and distant metastasis-free survival (DMFS). Several parameters' impact on these outcomes was assessed. Materials and Methods: Fifty-six patients with LAPC undergoing SBRT+/-CHT were included. SBRT median BED alpha/beta 10Gy was 48.0 Gy (range=28.0-78.7). Survival curves were calculated by Kaplan-Meier method. A Cox regression model was fitted. Results: At a median follow-up of 15.0 months, 2-year OS, LC, DMFS were: 33.8% 55.4%, and 22.9%, respectively. Patients treated with BED alpha/beta 10Gy >= 48 Gy showed improved OS (p=0.020) and LC (p=0.024). At multivariate analysis, BED alpha/beta 10Gy >= 48 Gy was significantly associated to both higher OS (p=0.042) and LC (p=0.045), while post-SBRT CHT improved DMFS (p=0.003). Conclusion: SBRT proved to be tolerable and effective in LAPC. Moreover, BED alpha/beta 10Gy >= 48 Gy was significantly correlated with improved OS and LC.
机译：目的：目前的多中心研究的目的是在局部晚期胰腺癌（LAPC）中审查有或没有化疗（CHT）经验的立体定向体放射治疗（SBRT）。终点是总存活（OS），局部对照（LC）和远处转移存活（DMF）。评估了几个参数对这些结果的影响。材料和方法：含有56例患有SBRT +/-CHT的LAPC患者。 SBRT中位数床Alpha / Beta 10Gy为48.0 GY（范围= 28.0-78.7）。通过Kaplan-Meier方法计算生存曲线。安装了COX回归模型。结果：在15.0个月的中位随访，2年OS，LC，DMFS分别为：33.8％55.4％和22.9％。用床α/β10Gy处理的患者= 48GY显示出改进的OS（P = 0.020）和LC（P = 0.024）。在多变量分析中，床α/β10Gy> = 48 Gy与较高的OS（P = 0.042）和LC（p = 0.045）显着相关，而SBRTCHT改善DMF（P = 0.003）。结论：SBRT在LAPC中被证明是可忍受和有效的。此外，床α/β10Gy> = 48 Gy与改进的OS和LC显着相关。

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