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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Confirmatory Analysis of QUARTZ Study Results: Survival Prolongation After Whole-brain Radiotherapy
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Confirmatory Analysis of QUARTZ Study Results: Survival Prolongation After Whole-brain Radiotherapy

机译：石英研究结果的确认分析：全脑放射后生存延长

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Background/Aim: The aim of this study was to analyze the survival of patients with brain metastases treated with best supportive care or additional whole-brain radiotherapy (WBRT), in order to confirm results from the prospective randomized QUARTZ study, which suggested prolonged survival after WBRT (5 fractions of 4 Gy) if favorable prognostic factors were present (age younger than 60 years, graded prognostic assessment score 2.5-3 points). Patients and Methods: We performed a retrospective single institution analysis of 76 patients with favorable prognosis. In contrast to the QUARTZ trial, inclusion was not limited to patients with non-small cell lung cancer (NSCLC). Furthermore, a cohort treated with higher total doses of WBRT was included (10 fractions of 3 Gy). Results: All patients were younger than 60 years or had a graded prognostic assessment score of 2.5-3. The median survival was significantly shorter after best supportive care (1.2 months; 3.2 months after WBRT with 5 fractions of 4 Gy and 3.9 months after 10 fractions of 3 Gy). Also, in multivariate analyses, survival was significantly better after WBRT. Further favorable prognostic factors included better performance status, no or limited extracranial metastases and primary tumor other than gastrointestinal. Conclusion: In line with the QUARTZ trial results, WBRT prolonged survival in patients with favorable prognostic features.
机译：背景/目的：本研究的目的是分析患有最佳支持性护理或额外全脑放射治疗（WBRT）治疗的脑转移患者的存活，以便确认前瞻性随机石英研究的结果，这表明延长了生存在WBRT（5分数为4 GY）之后，如果存在有利的预后因素（年龄小于60岁，预后预后评估2.5-3分）。患者和方法：我们对76例患者进行了回顾性单一机构分析，患有了良好的预后。与石英试验相比，包含不限于非小细胞肺癌（NSCLC）的患者。此外，包括较高总剂量的WBRT处理的群组（10分级别为3 Gy）。结果：所有患者均超过60岁或分级预后评估得分为2.5-3。在最佳支持性护理后，中位存活率明显缩短（1.2个月; 3.2个月后WBRT，5分数为4 Gy和3 Gy的10分之后3.9个月）。此外，在多变量分析中，WBRT后存活率明显更好。进一步有利的预后因素包括更好的性能状态，无或有限的颅外转移和胃肠道以外的原发性肿瘤。结论：符合石英试验结果，WBRT延长了患者的患者的良好预后特征。

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