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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Relevance of Vitamin D in Melanoma Development, Progression and Therapy
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Relevance of Vitamin D in Melanoma Development, Progression and Therapy

机译:维生素D在黑色素瘤发育,进展和治疗中的相关性

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摘要

Melanoma is one of the most lethal types of skin cancer, with a poor prognosis once the disease enters metastasis. The efficacy of currently available treatment schemes for advanced melanomas is low, expensive, and burdened by significant side-effects. Therefore, there is a need to develop new treatment options. Skin cells are able to activate vitamin D via classical and non-classical pathways. Vitamin D derivatives have anticancer properties which promote differentiation and inhibit proliferation. The role of systemic vitamin D in patients with melanoma is unclear as epidemiological studies are not definitive. In contrast, experimental data have clearly shown that vitamin D and its derivatives have anti-melanoma properties. Furthermore, molecular and clinicopathological studies have demonstrated a correlation between defects in vitamin D signaling and progression of melanoma and disease outcome. Therefore, adequate vitamin D signaling can play a role in the treatment of melanoma.
机译:黑色素瘤是一种最致命类型的皮肤癌之一,一旦疾病进入转移,预后差。 目前可用的治疗方案对先进的黑色素瘤的疗效低,昂贵,并且通过显着的副作用负担。 因此,需要开发新的治疗方案。 皮肤细胞能够通过经典和非古典途径激活维生素D. 维生素D衍生物具有抗癌性质,可促进分化和抑制增殖。 Sysoic维生素D在黑素瘤患者中的作用尚不清楚,因为流行病学研究并非明确。 相比之下,实验数据已经清楚地表明,维生素D及其衍生物具有抗黑色素瘤性质。 此外,分子和临床病理学研究表明了维生素D信号传导与黑素瘤和疾病结果的缺陷之间的相关性。 因此,足够的维生素D信号传导可以在黑色素瘤的治疗中起作用。

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