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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Hepatic Stellate Cells Contribute to the Tumor Malignancy of Hepatocellular Carcinoma Through the IL-6 Pathway
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Hepatic Stellate Cells Contribute to the Tumor Malignancy of Hepatocellular Carcinoma Through the IL-6 Pathway

机译：肝星状细胞通过IL-6途径有助于肝细胞癌的肿瘤恶性肿瘤

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Background/Aim: The hepatic stellate cells (HSCs) have relationship to cancer progression. The aim of this study is to investigate the effect of HSCs and the role of IL-6/Stat3 pathway on hepatocellular carcinoma (HCC) progression. Materials and Methods: HCCs were co-cultured with HSCs. The viability and migration ability of cancer cells were detected. Epithelial-mesenchymal transition (EMT) marker (E-cadherin), stem cell marker (CD44) and p-signal transducer and activator of transcription 3 (p-STAT3) of cancer cells were evaluated. Finally, interleukin-6 (IL-6) neutralization was performed. Results: Co-culture of HCCs with HSCs increased cancer cell viability and migration ability. EMT and stemness of cancer cells increased with HSCs. Following IL-6 neutralization, phospho-STAT3 activation, cancer cell viability and migration, as well as EMT, and stemness of cancer cells decreased. Conclusion: HSCs promoted HCC progression through the IL-6/STAT3 pathway.
机译：背景/目的：肝星状细胞（HSCs）与癌症进展有关系。 本研究的目的是探讨HSC的作用和IL-6 / Stat3途径对肝细胞癌（HCC）进展的作用。 材料和方法：HCC与HSC共同培养。 检测癌细胞的活力和迁移能力。 上皮 - 间充质转换（EMT）标记（E-CDADHERIN），癌细胞的转录3（P-STAT3）的干细胞标记物（CD44）和P信号传感器和活化剂。 最后，进行白细胞介素-6（IL-6）中和。 结果：HCCS与HSC的共同培养增加癌细胞活力和迁移能力。 癌细胞的EMT和茎秆随HSC的增加。 在IL-6中和之后，磷酸毒剂3激活，癌细胞活力和迁移，以及癌细胞的茎和茎秆降低。 结论：HSC通过IL-6 / Stat3途径促进了HCC进展。

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