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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans
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Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans

机译：IL-10启动子的遗传多态性与非洲裔美国人的吸烟和前列腺癌风险有关

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Background/Aim: Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the association of five SNPs in the IL-10 promoter with clinical features such as Gleason score and smoking. Materials and Methods: A total of 413 DNA samples were obtained from a nested case-control study of African American males who were genotyped for 5 SNPs utilizing pyrosequencing. Multiple and binary logistic regression models were applied to analyze the clinical and genotypic data. Results: rs12122923 and rs1800871 were associated with PCa risk. Smoking was also found to increase the risk of PCa by 1.6-fold. rs1800893 was found to be associated with lower grades for prostate cancer. Conclusion: IL-10 promoter polymorphisms might be a risk factor for PCa development in smoking subjects and PCa progression.
机译：背景/目的：即使前列腺癌（PCA）预后良好，族群风险都存在差异，具有非洲裔美国人的高发病率。白细胞介素10（IL-10）中的单核苷酸多态性（SNP）与炎症和癌症风险有关。我们调查了在IL-10启动子中的五个SNP的关联，临床特征如Gleason评分和吸烟等。材料和方法：共有413个DNA样品，从嵌套的非洲裔美国男性的嵌套病例对照研究获得，用于利用焦肌肉进行5个SNP的基因分型。应用多个和二进制逻辑回归模型来分析临床和基因型数据。结果：RS12122923和RS1800871与PCA风险有关。还发现吸烟将PCA的风险增加1.6倍。发现RS1800893与前列腺癌的较低等级有关。结论：IL-10启动子多态性可能是吸烟受试者和PCA进展中PCA开发的危险因素。

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