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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Progressive Disease in Sentinel-negative Melanoma Patients: Biological Differences and Importance of Sentinel Lymph Node Biopsy
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Progressive Disease in Sentinel-negative Melanoma Patients: Biological Differences and Importance of Sentinel Lymph Node Biopsy

机译：Sentinel阴性黑色素瘤患者的渐进性疾病：Sentinel淋巴结活检的生物差异和重要性

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Background/Aim: Among the most important prognostic factors in melanoma is the sentinel lymph node (SLN) status. Materials and Methods: Using our electronic database we identified 109 of 890 SLN-negative patients with progressive disease (PD). These patients were characterized for melanoma type, molecular type, sequence and extent of metastatic spread. Results: A total of 61 of 109 SLN-negative patients had PD in the SLN-basin indicating false-negative SLN (group-1). Forty eight of 109 patients had PD at distant sites and were therefore impossible to be identified using SLN biopsy (group-2). Despite distant spread these patients had significantly more single organ metastasis (p<0.001) and significantly longer disease-free-survival (p=0.001) compared to group-1. Additionally, to significant differences on a molecular basis between the two groups (p=0.01), all lentigo maligna and spindle-cell-melanomas belonged to group-2 and all, except one lentigo maligna melanoma, had single visceral metastasis. Conclusion: Two different biological groups among SLN-negative patients with PD were demonstrated. Extravascular-migratory-metastasis, rather than hematogenous spread, might be responsible for the observed PD with single organ involvement.
机译：背景/目标：黑素瘤中最重要的预后因素是Sentinel淋巴结（SLN）状态。材料和方法：使用我们的电子数据库，我们确定了890例渐进性疾病（PD）的890名SLN阴性患者。这些患者的特征是黑色素瘤类型，分子类型，转移扩散的序列和程度。结果：总共61例109个SLN阴性患者在SLN-盆地中具有PD，指示假阴性SLN（组-1）。在远处部位的48名患者中有48名患者在遥远的位置具有PD，因此不可能使用SLN活组织检查（组-2）来鉴定。尽管远处传播，但这些患者的单个器官转移（P <0.001）显着更长，与第1组相比，无疾病存活率（p = 0.001）。另外，在两组（P = 0.01）之间的分子基础上的显着差异（p = 0.01），除了氯尼奥马拉尼亚黑色素瘤之外，所有氟戈马尔和纺织细胞 - 黑色素组属于2组，均为单一的内脏转移。结论：对PD的SLN阴性患者进行两种不同的生物学群。血管外 - 迁移 - 转移，而不是血源性传播，可能对观察到的PD有单个器官受累。

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