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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Prognostic Significance of Tumor Immunity in Surgically Resected Pulmonary Pleomorphic Carcinoma
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Prognostic Significance of Tumor Immunity in Surgically Resected Pulmonary Pleomorphic Carcinoma

机译：肿瘤免疫在手术切除肺五形癌中的预后意义

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Background: Pulmonary pleomorphic carcinoma (PPC) is a rare aggressive neoplasm, with dismal prognosis. Whether tumor immunity is associated with the progressive biological behavior of PPC remains unclear. The purpose of this study was to examine the prognostic significance of tumor immunity-related markers such as programmed death-1 ligand (PD-L1) and CD4(+) or CD8(+) tumor-infiltrating lymphocytes (TILs) in patients with surgically resected PPC. Patients and Methods: Ninety-nine patients with surgically resected PPC were assessed by immunohistochemistry. The expression of PDL1, CD4, and CD8 was examined in specimens of the resected tumors. Results: PD-L1 was highly expressed in 61% (60/99) of lesions and high expression of CD4 and CD8 was identified in 42% (42/99) and 51% (51/99) of lesions, respectively. There was no relationship between the expression PD-L1 and the numbers of CD4(+) or CD8(+) TILs. The expression of PD-L1 was not identified as a significant prognostic marker; however, a low number of CD4(+) TILs was identified as an independent marker for predicting a worse outcome after surgical resection of PPC, especially in patients with an epithelial component of adenocarcinoma or early stage of disease. By univariate analysis, a low number of CD8(+) TILs was found to be a significant prognostic marker linked to poor overall survival in patients with non-adenocarcinoma components. Conclusion: A low number of CD4(+) TILs is an independent marker for predicting a favorable prognosis after surgical resection in patients with PPC, especially in patients with adenocarcinoma components or early stage of disease.
机译：背景：肺五形癌（PPC）是一种罕见的侵袭性肿瘤，具有令人沮丧的预后。肿瘤免疫是否与PPC的渐进生物学行为有关。本研究的目的是检查肿瘤免疫相关标志物如手术患者中编程死亡-1配体（PD-L1）和CD8（+）肿瘤浸润淋巴细胞（TILS）的预后意义切除PPC。患者及方法：通过免疫组织化学评估九十九患有手术切除的PPC患者。在切除的肿瘤的标本中检查PDL1，CD4和CD8的表达。结果：PD-L1在61％（60/99）的病变中高度表达，CD4和CD8的高表达分别在42％（42/99）和51％（51/99）的病变中鉴定出来。表达PD-L1与CD4（+）或CD8（+）直到的数量之间没有关系。 PD-L1的表达未被鉴定为显着的预后标志物;然而，少量的CD4（+）直线被鉴定为独立标记物，用于预测PPC的外科切除后的较差的结果，特别是在腺癌的上皮组分或疾病早期阶段的患者中。通过单变量分析，发现少量的CD8（+）直线是具有非腺癌组分患者的总体存活差的重要预后标志物。结论：少量CD4（+）直线是一种独立的标记，用于预测PPC患者手术切除后的良好预后，特别是在腺癌组分或疾病早期阶段的患者中。

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