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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >New Pancreatic Cancer Biomarkers eIF1, eIF2D, eIF3C and eIF6 Play a Major Role in Translational Control in Ductal Adenocarcinoma
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New Pancreatic Cancer Biomarkers eIF1, eIF2D, eIF3C and eIF6 Play a Major Role in Translational Control in Ductal Adenocarcinoma

机译：新的胰腺癌生物标志物EIF1，EIF2D，EIF3C和EIF6在导管腺癌中的翻译控制中起主要作用

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Background/Aim: Pancreatic cancer is one of the deadliest forms of cancer and ranks among the leading causes of cancer-related death worldwide. The most common histological type is ductal adenocarcinoma (PDAC), accounting for approximately 95% of cases. Deregulation of protein synthesis has been found to be closely related to cancer. The rate-limiting step of translation is initiation, which is regulated by a broad range of eukaryotic translation initiation factors (eIFs). Patients and Methods: Human PDAC samples were biochemically analyzed for the expression of various eIF subunits on the protein level (immunohistochemistry, immunoblot analyses) in 174 cases of PDAC in comparison with non-neoplastic pancreatic tissue (n=10). Results: Our investigation revealed a significant down-regulation of four specific eIF subunits, namely eIF1, eIF2D, eIF3C and eIF6. Concomitantly, the protein (immunoblot) levels of eIF1, eIF2D, eIF3C and eIF6 were reduced in PDAC samples as compared with non-neoplastic pancreatic tissue. Conclusion: Members of the eIF family are of relevance in pancreatic tumor biology and may play a major role in translational control in PDAC. Consequently, they might be useful as potential new biomarkers and therapeutic targets in PDAC.
机译：背景/目的：胰腺癌是最致命的癌症形式之一，是全世界癌症相关死亡的主要原因。最常见的组织学型是导管腺癌（PDAC），占案件的约95％。已发现蛋白质合成的放松管制与癌症密切相关。转换率限制步骤是启动，其由广泛的真核翻译启动因子（EIFs）调节。患者和方法：人类PDAC样品对174例PDAC蛋白水平（免疫组织化学，免疫印迹分析）的各种EIF亚基进行生化分析，与非肿瘤胰腺组织（n = 10）相比。结果：我们的调查显示了四个特定EIF亚基的显着下调，即EIF1，EIF2D，EIF3C和EIF6。同时，与非肿瘤胰组织相比，在PDAC样品中，eIF1，EIF2D，EIF3C和EIF6的蛋白质（免疫印迹）水平降低。结论：EIF家族的成员在胰腺肿瘤生物学中具有相关性，并且可能在PDAC的翻译控制中发挥重要作用。因此，它们可能是PDAC中潜在的新生物标志物和治疗靶标。

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