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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Association of Vitamin D Receptor Gene Polymorphisms With Melanoma Risk: A Meta-analysis and Systematic Review
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Association of Vitamin D Receptor Gene Polymorphisms With Melanoma Risk: A Meta-analysis and Systematic Review

机译：与黑素瘤风险的维生素D受体基因多态性的关联：Meta分析和系统审查

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Background/Aim: Increasing evidence indicates a relevance of the vitamin D endocrine system for pathogenesis of malignant melanoma. We performed a systematic review and meta-analysis to update previous reports that investigated the association between vitamin D receptor (VDR) gene polymorphisms and melanoma risk. Materials and Methods: A comprehensive literature search (PubMed, ISI Web of Science) identified a total of 14 studies that were eligible for inclusion in our meta-analysis. In the statistical analysis, the ORs and the 95% CIs were calculated for the dominant and recessive models for seven VDR gene polymorphisms, namely rs2228570 (FokI), rs731236 (TaqI), rs1544410 (BsmI), rs4516035 (A-1012G), rs11568820 (Cdx2), rs7975232 (ApaI) and rs739837 (BglI). Results were illustrated in Forest Plots. Publication bias was tested using Funnel Plots and the Egger's test. Results: Our meta-analysis showed in the dominant model (Bb + BB vs. bb) a significant association of a 15% risk reduction in malignant melanoma incidence for carriers of the rarer allele B of rs1544410 (Bsml). Notably, the dominant model (Ff + ff vs. FF) of rs2228570 (FokI) demonstrates that carriers of the rarer allele f are 22% more likely to develop malignant melanoma. For rs7975232 (ApaI), there is a 20% higher risk of melanoma for carriers of the rarer a allele (Aa + aa vs. AA). The results of the meta-analysis revealed no significant association between melanoma risk and the other investigated VDR polymorphisms. Conclusion: The VDR variants FokI, ApaI and BsmI may influence the susceptibility to developing melanoma. These findings support the concept, that the vitamin D endocrine system is of importance for pathogenesis of malignant melanoma.
机译：背景/目的：越来越多的证据表明了恶性黑素瘤发病机制的维生素D内分泌系统的相关性。我们进行了系统审查和Meta分析，以更新先前的报告，以研究维生素D受体（VDR）基因多态性和黑素瘤风险之间的关联。材料和方法：全面的文献搜索（PubMed，Isi Web）确定了14项研究，其中有资格包含在我们的荟萃分析中。在统计分析中，计算七个VDR基因多态性的主导和隐性模型的统计学分析和95％CI，即RS2228570（FOKI），RS731236（TAQI），RS1544410（BSMI），RS4516035（A-1012G），RS11568820 （CDX2），RS7975232（APAI）和RS739837（BGLI）。结果在森林地块中说明。使用漏斗图和EGGER测试测试出版物偏差。结果：我们的META分析显示在主导模型（BB + BB vs.BB）中显示出rARER等位基因B rs154410（BSML）的载体的恶性黑素瘤发生率的15％风险降低。值得注意的是，RS2228570（FOKI）的主导模型（FF + FF与FF）表明，雷达等位基因F的载体可能更容易产生恶性黑色素瘤。对于RS7975232（Apai），对于罕见的rarele（AA + AA对AA）的载体，对黑色素瘤的风险增加了20％。 Meta分析的结果显示黑素瘤风险与其他调查的VDR多态性之间没有显着关联。结论：VDR变体Foki，Apai和BSMI可能影响发展黑素瘤的易感性。这些发现支持该概念，维生素D内分泌系统对恶性黑素瘤的发病机制是重要的。

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