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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >In Vitro Analysis of the Combinatory Effects of Novel Aminonaphthoquinone Derivatives and Curcumin on Breast Cancer Progression
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In Vitro Analysis of the Combinatory Effects of Novel Aminonaphthoquinone Derivatives and Curcumin on Breast Cancer Progression

机译：新型氨基萘醌衍生物和姜黄素对乳腺癌进展的组合作用的体外分析

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Background/Aim: We previously reported the potential of aminonaphthoquinone derivatives as therapeutic agents against breast and other oestrogen-responsive tumours when combined with curcumin. This study aimed at screening of novel aminonaphthoquinone derivatives (Rau 008, Rau 010, Rau 015 and Rau 018) combined with curcumin for cytotoxic, anti-angiogenic and anti-metastatic effects on MCF-7 and MDA-MB- 231 breast cancer cells. Materials and Methods: Cytotoxic and anti-angiogenic effects were analysed using the 3-(4,5- dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide assay and enzyme-linked immunosorbent assay; while anti-metastatic effects were measured using adhesion assay, Boyden chambers and Matrigel. Results: Curcumin combined with Rau 008 elicited marked cytotoxic effects in MCF-7 cells compared with the individual treatments, whereas when it was combined with Rau 015 and with Rau 018, it displayed similar effects in MDA-MB-231 cells. The anti- angiogenic effect of Rau 015 plus curcumin in MCF-7 cells and Rau 018 plus curcumin in MDA-MB- 231 cells was more effective than individual treatments, while the metastatic capability of MDA-MB-231 cells was significantly reduced after treatment with the aminonaphthoquinone-curcumin combinations. Conclusion: Aminonaphthoquinones may offer significant promise as therapeutic agents against breast cancer, particularly when combined with curcumin.
机译：背景/目的：在与姜黄素结合时，我们之前报道了氨基碱基醌衍生物作为治疗剂对乳腺癌和其他雌激素响应性肿瘤的潜力。本研究旨在筛选新型氨基碱基醌衍生物（RAU 008，RAU 010，RAU 015和RAU 018），所述姜黄素与MCF-7和MDA-MB-231乳腺癌细胞的细胞毒性，抗血管生成和抗转移效应相结合。材料和方法：使用3-（4,5-二甲基噻唑-2-基）2,5-二苯基四唑溴铵测定和酶联免疫吸附测定分析细胞毒性和抗血管生成效果;虽然使用粘附测定，Boyden腔室和Matrigel测量抗转移效果。结果：与RAU 008结合RAU 008在MCF-7细胞中引发了显着的细胞毒性，而与个体治疗相比，当与RAU 015和RAU 018结合时，它在MDA-MB-231细胞中显示出类似的效果。在MDA-MB-231细胞中，RAU 015加姜黄素和RAU 018加姜黄素在MDA-MB-231细胞中的抗血管生成效果比个体处理更有效，而MDA-MB-231细胞的转移能力在治疗后显着降低用氨基萘醌 - 姜黄素组合。结论：氨基萘醌可以作为乳腺癌的治疗剂，特别是当与姜黄素相结合的疗效。

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