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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >The Rectus Sheath Block (RSB) Analgesia Following Laparotomy Could Affect Malonidialdehyde (MDA) Concentrations in Benign Disease and Cancer
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The Rectus Sheath Block (RSB) Analgesia Following Laparotomy Could Affect Malonidialdehyde (MDA) Concentrations in Benign Disease and Cancer

机译：剖腹术后的循环鞘块（RSB）镇痛可能会影响良性疾病和癌症中的恶性丙醛（MDA）浓度

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Background/Aim: The aim of the study was to compare the MDA (malonidialdehyde) plasma concentrations versus CAT (catalase)/NT (nitrotyrosine) plasma concentrations, patient satisfaction and pain score at rest/pressure to the wound area in laparotomy patients with rectus sheath block (RSB) analgesia. Patients and Methods: Initially, 56 patients were randomized to four groups; control group (n=12), single-dose (n=16), repeated-dose (n=12) and continuous infusion (n=16) RSB analgesia groups. The plasma concentrations of CAT, NT and MDA markers were measured just before, immediately after and 24 h after operation. Results: The RSB analgesia enhanced significantly patient satisfaction (p=0.001). The plasma MDA decreased immediately after operation ( POP1) and the postoperative decrease between the preoperative and the POP1 values in the MDA marker were statistically significant (p<0.001). In linear mixed model, the time effect in both the single group and in the benign group in plasma NT biomarker was statistically significant (p=0.001, p=0.013, respectively). The median plasma MDA concentrations ( ng/ml) following surgery were significantly lower in patients with cancer versus patients with benign disease (589 vs. 852, p=0.021). Jitterplots of the individual plasma NT versus plasma MDA showed that there was significant correlation in benign and cancer patients (r=0.347, p<0.001). Conclusion: Plasma MDA decreased significantly after operation in all patients and cancer patients had significantly lower MDA concentrations following surgery than patients with benign disease.
机译：背景/目的：该研究的目的是将MDA（Malonidialdehyde）血浆浓度与猫（过氧化氢酶）/ NT（硝基荧光蛋白）血浆浓度，患者满意度和疼痛评分在休息/压力下对剖腹症患者的伤口区域进行静止/压力鞘块（RSB）镇痛。患者及方法：最初，56名患者随机分为四组;对照组（n = 12），单剂量（n = 16），重复剂量（n = 12）和连续输注（n = 16）RSB镇痛组。在手术后立即测量猫，NT和MDA标志物的血浆浓度。结果：RSB镇痛增强显着患者满意度（P = 0.001）。在术后（POP1）之后，等离子体MDA在术前（POP1）和MDA标记中的术前和POP1值之间的术后减少统计学意义（P <0.001）。在线性混合模型中，单个组和血浆NT生物标志物中良性组的时间效应具有统计学意义（P = 0.001，P = 0.013）。癌症与良性疾病患者（589 vs.852，P = 0.021）的癌症患者，手术中的等血浆MDA浓度（Ng / ml）显着降低。个体血浆NT与等离子体MDA的统计潮点表明，良性和癌症患者的相关性显着（r = 0.347，p <0.001）。结论：血浆MDA在所有患者的操作后显着降低，癌症患者比良性疾病的患者在手术后显着降低了MDA浓度。

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