...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >The Significant Association of MMP-1 Genotypes With Taiwan Pterygium
【24h】

The Significant Association of MMP-1 Genotypes With Taiwan Pterygium

机译：与台湾翼状胬肉的MMP-1基因型的重要关联

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background/Aim: Few studies have examined the contribution of matrix metalloproteinases (MMP) to either diagnosis or prognosis of pterygium. The aim of this study was to investigate the contribution of MMP-1 genotypes to pterygium risk. Patients and Methods: A total of 134 cases and 268 controls were included and their MMP-1-1607 (rs1799705) genotypes were examined by polymerase chain reaction-restriction fragment length polymorphism. Results: The percentages of 2G/2G, 1G/2G, and 1G/1G for rs1799705 genotypes were 48.5, 36.6 and 14.9% among patients and 33.9, 44.8, and 21.3% among controls (p trend=0.0167). The odds ratios (ORs) after adjusting for age and gender for 1G/2G and 1G/1G genotypes at rs1799705 were 0.54 (95%CI=0.33-0.89, p=0.0168) and 0.46 (95%CI=0.27-0.88, p=0.0192), respectively. Consistently, the adjusted OR for those carrying the 1G allele at MMP-1 -1607 was 0.61 (95%CI=0.41-0.78, p=0.0167), compared with the wild-type 2G allele. Conclusion: The genotypes at rs1799705 play a role in determining personal susceptibility to pterygium.
机译：背景/目的：少数研究检测了基质金属蛋白酶（MMP）对翼状胬肉的诊断或预后的贡献。本研究的目的是探讨MMP-1基因型对翼状胬肉风险的贡献。患者和方法：共用134例和268例，通过聚合酶链反应限制片段长度多态性检查其MMP-1-1607（RS1799705）基因型。结果：1799705基因型2g / 2g，1g / 2g和1g / 1g的百分比为48.5,36.6％和14.9％，33.9,44.8和21.3％（p趋势= 0.0167）。调整1G / 2G和1G / 1G基因型的年龄和性别后的差距比率（OR）为0.54（95％CI = 0.33-0.89，P = 0.0168）和0.46（95％CI = 0.27-0.88，P分别= 0.0192）。与野生型2G等位基因相比，始终如一地，携带1G等位基因的调节或用于携带的1G等位基因的人数为0.61（95％CI = 0.41-0.78，P = 0.0167）。结论：RS1799705的基因型在确定对翼状胬肉的个人易感性方面发挥作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号