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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Predictors of Outcome in Patients With Fibrolamellar Carcinoma: Analysis of the National Cancer Database
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Predictors of Outcome in Patients With Fibrolamellar Carcinoma: Analysis of the National Cancer Database

机译：纤维素癌患者的结果预测因素：国家癌症数据库分析

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Background: Fibrolamellar carcinoma (FLC) is a very rare liver tumor. We aimed to retrospectively analyze the clinicopathological factors and treatment modalities affecting overall survival (OS) in FLC. The objective of the study was to identify predictors of survival in FLC. Patients and Methods: Using the National Cancer Database, we identified 496 patients diagnosed with FLC between 2004 and 2015. Clinicopathological, treatment, and survival data were collected. Results: Hepatic resection was performed on 254 (51.2%) patients, liver-directed therapy on 13 (2.6%) patients, and liver transplantation on 15 (3.0%) patients. Median OS by stage were 142.1, 87.2, 32.3, and 14.1 months for stages 1, 2, 3, and 4, respectively. Metastatectomy was not associated with superior median OS (23.4 vs. 10.5 months, p=0.163). Age <= 40, low Charlson-Deyo comorbidity score, early stage and hepatic resection were independently associated with longer OS. Conclusion: Our study reports current trends in FLC management, and identifies independent predictors of OS.
机译：背景：纤维素癌（FLC）是一种非常罕见的肝肿瘤。我们旨在回顾性地分析影响FLC整体存活（OS）的临床病理因子和治疗方式。该研究的目的是识别FLC中存活的预测因素。患者和方法：使用国家癌症数据库，我们确定了496名患者，诊断为2004年至2015年间FLC。收集临床病理学，治疗和存活数据。结果：肝切除在254名（51.2％）患者中进行，肝脏定向治疗13例（2.6％）患者，肝移植15（3.0％）患者。阶段的中位操作系统分别为142.1,87.2,32.3和14.1个月，分别为阶段1,2,3和4。转移切除术无与高级中值OS相关（23.4与10.5个月，P = 0.163）。年龄<= 40，低查理 - Deyo合并症评分，早期和肝切除术与较长的OS独立相关。结论：我们的研究报告了FLC管理的当前趋势，并确定了OS的独立预测因子。

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