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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >C-myc Contributes to Malignancy of Lung Cancer: A Potential Anticancer Drug Target
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C-myc Contributes to Malignancy of Lung Cancer: A Potential Anticancer Drug Target

机译：C-MYC导致肺癌的恶性肿瘤：潜在的抗癌药物目标

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摘要

Emerging evidence has provided important information on oncoproteins involved in cancer initiation, progression, metastasis, and resistance to current therapies. C-myc, one of the critical oncoproteins, has been shown to be implicated in enhancing the aggressiveness of many cancers, mainly through its ability to increase cancer cell growth and cellular survival mechanisms. Despite the more precise and earlier detection and the availability of better therapies, lung cancer remains the most dreadful cancer as it causes high mortality rate with relatively poor treatment success. In lung cancer, C-myc is frequently dysregulated and associated with unfavorable patient survival. C-myc plays a role in regulation of lung cancer cell behaviors including growth, resistance, death, and dissemination through the activation of cell cycle driving proteins, an increase in the cellular levels of antiapoptotic proteins, and the modulation of metabolism. Besides, C-myc has been shown to be important for cancer stem cell (CSC) properties. Taken together, targeting as well as inhibiting C-myc could provide promising means for resolving lung cancer. This review emphasizes on the molecular mechanism by which C-myc influences lung cancer growth, metastasis, drug resistance, and CSC maintenance, and suggests the target proteins that may benefit drug discovery and design.
机译：新兴的证据提供了关于癌蛋白的重要信息，参与癌症起始，进展，转移和对当前疗法的抵抗力。 C-Myc是临理癌蛋白之一，已被证明涉及提高许多癌症的侵袭性，主要是通过其增加癌细胞生长和细胞存活机制的能力。尽管检测得更精确和更好的检测和更好的疗法，但肺癌仍然是最令人恐惧的癌症，因为它导致高度死亡率具有相对较差的治疗成功。在肺癌中，C-Myc经常具有吸诵并与不利的患者存活相关。 C-MYC在调节肺癌细胞行为的调节作用，包括通过激活细胞周期驱动蛋白的生长，抗性，死亡和传播，增加抗菌蛋白的细胞水平和代谢的调节。此外，C-MYC已被证明对癌症干细胞（CSC）性能很重要。占有平，靶向和抑制C-MYC可以为解决肺癌提供有希望的手段。本综述强调C-MYC影响肺癌生长，转移，耐药性和CSC维持的分子机制，并表明可能有利于药物发现和设计的靶蛋白。

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