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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >High prevalence of human anti-mouse antibodies in the serum of colorectal cancer patients.
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High prevalence of human anti-mouse antibodies in the serum of colorectal cancer patients.

机译：结直肠癌患者血清中人抗小鼠抗体的高患病率。

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BACKGROUND: Monoclonal antibody treatment induces the expression of human anti-mouse antibodies (HAMA), which in turn interfere with the therapy. However, whether HAMAs are expressed before the initiation of antibody therapy in patients with colorectal cancer remains unknown. MATERIALS AND METHODS: Serum samples were collected from 40 patients diagnosed with colorectal cancer. Serum samples from 157 individuals without cancer were used as controls. None of the patients received imaging or therapeutic antibodies before the study. The expression of HAMAs was evaluated by ELISA with murine immunoglobulin G1 (mIgG)1, mIgG2a and mIgG2b as the antigen. RESULTS: Of the 40 colorectal cancer patients, 9 (22.5%) expressed either IgG- or IgM-type HAMAs while only 13/157 (8.2%) of the individuals without cancer expressed the HAMAs (p<0.05). CONCLUSION: HAMAs are prevalent in the serum of colorectal cancer patients even before antibody administration. Medical practitioners should be alert to the possibility of HAMA expression when administering antibody therapy.
机译：背景：单克隆抗体治疗诱导人抗小鼠抗体（HAMA）的表达，这又会干扰治疗。然而，在结肠直肠癌患者的抗体治疗开始之前是否表达哈马斯仍然未知。材料和方法：从诊断患有结直肠癌的40名患者中收集血清样品。 157个体没有癌症的血清样品用作对照。没有患者在研究之前接受过成像或治疗性抗体。哈马斯的表达是由ELISA与鼠免疫球蛋白G1（MIGG）1，MIGG2A和MIGG2B作为抗原的。结果：40例结直肠癌患者，9（22.5％）表达IgG-或IgM型哈马斯，而哈马斯仅表达了13/157（8.2％）的个体（P <0.05）。结论：哈马斯甚至在抗体给药前结直肠癌患者的血清普遍存在。医疗从业者应警惕施用抗体治疗时的HAMA表达的可能性。

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