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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Platinum-based Agent and Fluorouracil in Metastatic Breast Cancer: A Retrospective Monocentric Study with a Review of the Literature
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Platinum-based Agent and Fluorouracil in Metastatic Breast Cancer: A Retrospective Monocentric Study with a Review of the Literature

机译：转移性乳腺癌中的铂族代理和氟尿嘧啶：回顾性单眼研究，并对文献进行审查

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Background: The combination of platinum with 5-fluorouracil has scarcely been studied in metastatic breast cancer. As this combination does not lead to significant hepatic metabolism, in some clinical situations it may prove useful, especially in cases with liver dysfunction and an urgent clinical need for rapid tumor shrinkage. A retrospective study was conducted to evaluate the efficacy and safety of the combination of cisplatin and 5-fluorouracil in patients with metastatic breast cancer with significant alterations of biochemistry. Patients and Methods: A total of 109 patients with metastatic breast cancer and liver dysfunction were treated; time-to-progression, overall survival and trends in liver function were evaluated. Results: The median time-to-progression was 3.4 months, and median overall survival was 7.8 months. About 50% of patients obtained a complete, partial or stable biochemical response and 24 patients were subsequently able to receive additional therapies. Conclusion: Our results show that this therapeutic doublet represents a clinically effective, safe and well-tolerated treatment option for patients with metastatic breast cancer and liver dysfunction.
机译：背景：转移性乳腺癌中几乎没有研究过5-氟尿嘧啶的铂的组合。由于这种组合不会导致显着的肝脏代谢，在一些临床情况下，它可能证明有用，特别是在肝功能障碍的情况下，迫切需要快速肿瘤收缩的临床需求。进行了回顾性研究，以评估顺铂和5-氟尿嘧啶在转移乳腺癌患者中的疗效和安全性，具有显着改变的生物化学改变。患者和方法：治疗109例转移性乳腺癌和肝功能障碍;评估了肝功能的延时，整体存活率和趋势。结果：中位数的时间是3.4个月，中位数总生存率为7.8个月。大约50％的患者获得了完整，部分或稳定的生化反应，24名患者随后能够接受额外的疗法。结论：我们的研究结果表明，这种治疗性双峰代表了转移乳腺癌和肝功能障碍患者的临床有效，安全且耐受良好的治疗选择。

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