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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Risk Factors for Regional and Systemic Metastases in Patients with Sentinel Lymph Node-negative Melanoma
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Risk Factors for Regional and Systemic Metastases in Patients with Sentinel Lymph Node-negative Melanoma

机译：Sentinel淋巴结阴性黑色素瘤患者区域和全身转移的危险因素

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Background: Sentinel lymph node status is a strong prognostic factor in melanoma. However, up to 21% of sentinel lymph node-negative patients develop locoregional and distant metastases during follow-up. Aim: To analyze risk factors for locoregional and distant metastasis in patients with sentinel lymph node-negative melanoma. Patients and Methods: A total of 545 patients underwent sentinel lymph node biopsy (SNB) between 2005 and 2013 at our hospital. Data for 449 patients with a negative SNB were analyzed regarding risk factors and development of metastases. Followup was performed until 2016. Results: A total of 72 SNB-negative patients developed metastases, including 25 (34.7%) distant and 47 (63.3%) locoregional metastases. Locoregional metastases occurred earlier compared to distant metastases (with a mean of 24.2 and 23.5 months for regional lymph node and cutaneous metastases, respectively, vs. 31.4 months for distant metastases). Patients with metastases despite negative SNB had a greater tumor thickness (p=0.001), a higher rate of nodular melanoma (p=0.001), ulceration (p0.001), and were older (p=0.05) compared to SNB-negative patients without subsequent metastases. Out of SNB-negative patients, 16% developed metastases. Conclusion: Close clinical followup including sonography of the draining lymph node region is mandatory for melanoma patients regardless of SNB status.
机译：背景：Sentinel淋巴结状态是黑色素瘤的强烈预后因素。然而，高达21％的Sentinel淋巴结阴性患者在随访期间发育型户标和远处转移。目的：分析Sentinel淋巴结阴性黑色素患者患者患者患者患者和远端转移的风险因素。患者和方法：在我们医院2005年至2013年期间，共545名患者接受了左侧淋巴结活检（SNB）。分析了449例阴性SNB患者的危险因素和转移的发展。在2016年之前进行了随访。结果：总共72例SNB阴性患者开发出转移，包括25（34.7％）遥远和47（63.3％）型型转移。与远处转移相比，型型转移较早发生（分别为区域淋巴结和皮肤转移的平均24.2和23.5个月，与远处转移的31.4个月）。患者患者尽管存在负SNB，但具有更大的肿瘤厚度（p = 0.001），与SNB阴性患者相比，溃疡（P <0.001），溃疡（P <0.001）较高（P <0.001），较旧（P = 0.05）没有后续转移。出于SNB阴性患者，出现16％的转移。结论：紧密临床后续跟踪，包括排水淋巴结区域的超声检查是黑色素瘤患者的强制性，无论SNB状态如何。

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