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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Expression of Zinc Finger and BTB Domain-containing 7A in Colorectal Carcinoma
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Expression of Zinc Finger and BTB Domain-containing 7A in Colorectal Carcinoma

机译：锌指和含有BTB结构域7A在结肠直肠癌中的表达

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摘要

Background/Aim: Previous studies have revealed that zinc finger and BTB domain-containing 7A (ZBTB7A), an important proto-onco gene, plays multiple roles in carcinogenesis and is up-regulated in several human malignancies. However, the expression of ZBTB7A in colorectal carcinoma (CRC) has seldom been documented. In this study, we investigated the differential expression of ZBTB7A in CRC cell lines and tissues. Materials and Methods: Expression levels of ZBTB7A mRNA and protein were examined in CRC cell lines. ZBTB7A protein expression was also evaluated in tissue samples of normal colonic mucosa, high-grade dysplasia, and CRC using immunohistochemical staining. Results: All CRC cell lines exhibited significantly higher ZBTB7A mRNA expression levels than did normal colonic epithelial cells. The ZBTB7A protein expression levels were clearly higher in the CRC cell lines than in the normal colonic epithelial cells. Consistent with the cell line data, immunostaining revealed that there were significant differences in ZBTB7A protein expression between tissue samples of CRC and normal colonic mucosa (p=0.048) and high-grade dysplasia (p=0.015). In addition, metastatic CRC exhibited significantly higher ZBTB7A protein expression levels than primary CRC (p=0.027). Conclusion: We demonstrated that ZBTB7A expression is up-regulated in CRC cell lines and tissues. Our data suggest that ZBTB7A is involved in the development and progression of CRC.
机译：背景/目的：以前的研究表明，锌手指和含有BTB结构域的7A（ZBTB7A）是一个重要的原核基因，在癌发生中起多种作用，并在几种人类恶性肿瘤中调高。然而，ZBTB7A在结肠直肠癌（CRC）中的表达很少被记录。在这项研究中，我们研究了ZBTB7A在CRC细胞系和组织中的差异表达。材料和方法：在CRC细胞系中检查ZBTB7A mRNA和蛋白质的表达水平。还评估了ZBTB7A蛋白表达，在正常结肠粘膜，高级发育不良和使用免疫组化染色的CRC的组织样品中评价。结果：所有CRC细胞系均显着高于正常结肠上皮细胞的ZBTB7A mRNA表达水平。 CRC细胞系ZBTB7A蛋白表达水平显着高于正常的结肠上皮细胞。与细胞系数据一致，免疫染色揭示了CRC和正常结肠粘膜组织样品之间的ZBTB7A蛋白表达存在显着差异（P = 0.048）和高级发育不良（P = 0.015）。此外，转移CRC显着高于初级CRC的ZBTB7A蛋白表达水平（P = 0.027）。结论：我们证明ZBTB7A表达在CRC细胞系和组织中升级。我们的数据表明，ZBTB7A参与了CRC的开发和进展。

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