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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Treatment of Adrenal Metastases with Conventional or Hypofractionated Image-guided Radiation Therapy - Patterns and Outcomes
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Treatment of Adrenal Metastases with Conventional or Hypofractionated Image-guided Radiation Therapy - Patterns and Outcomes

机译：用常规或次要的图像引导式放射治疗的肾上腺转移处理 - 模式和结果

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Background/Aim: Metastases involving the adrenal glands can be treated surgically or with radiation therapy. Retrospective studies indicate that radiotherapy for this indication is safe, well-tolerated and associated with symptom palliation and good local control. We conducted this analysis to report on patterns and outcomes of patients with adrenal metastases treated with hypo- or conventionally fractionated image-guided radiotherapy. Patients and Methods: Patients with adrenal metastases from solid tumors treated at our department between 01/2010-12/2017 were reviewed. A total of 22 lesions were treated in 18 patients with a median dose of 35 Gy (20-60 Gy) in a median number of 7 (4-25) fractions. Results: No grade = 3 toxicity occurred. Median overall survival was 11.9 months. Five local failures occurred (22.7%). Lesion sizes or radiation dose were not correlated with local control. Patients treated for oligometastatic and oligoprogressive disease had a median overall survival of 33 and 6.5 months, respectively (palliative/polymetastatic: 1.6 months). Symptoms improved in all patients treated for clinically apparent lesions. Conclusion: Stereotactic radiotherapy of adrenal metastases was safe and effective in patients with oligometastases or oligoprogression. In palliative patients, short-course radiotherapy complemented with supportive care should be preferred.
机译：背景/目的：涉及肾上腺的转移可以通过手术或放射治疗治疗。回顾性研究表明，这种指示的放射治疗是安全的，耐受性，与症状痛苦和良好的局部控制相关。我们进行了该分析，报告了用诸如常规分级分级的图像引导放射治疗治疗的肾上腺转移患者的模式和结果。患者及方法：审查了在我们部门在01 / 2010-12 / 2017之间治疗的固体肿瘤的肾上腺转移患者进行了审查。在18名患者中，共有22例患有25例，中位数为35 Gy（20-60Gy），中值7（4-25）分数。结果：没有等级＆ = 3次毒性。中位数总生存率为11.9个月。发生了五个局部失败（22.7％）。病变尺寸或辐射剂量与局部对照无关。治疗寡粒子和寡聚疾病的患者分别具有33和6.5个月的中位数生存率（姑息/多孢子：1.6个月）。症状在临床上视表位病变治疗的所有患者中有所改善。结论：肾上腺转移的立体定向放射疗法在寡粒子或寡次抗争的患者中是安全可有效的。在姑息患者中，应优选辅以支持性护理的短程放射疗法。

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