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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Depression in Choroidal Melanoma Patients Treated with Proton Beam Radiotherapy
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Depression in Choroidal Melanoma Patients Treated with Proton Beam Radiotherapy

机译：脉络膜黑色瘤患者抑郁症患者用质子梁放射治疗

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Aim: To determine depression in patients with choroidal melanoma (CM) treated with proton beam radiotherapy. Patients and Methods: This was a cross-sectional study including 50 patients with CM (50% males, mean age=49.88 +/- 6.34 years) and 46 age- and sex-matched healthy controls (52% males, mean age=48.60 +/- 8.05 years). Participants completed the Patient Health Questionnaire-9 (PHQ-9) and the Zung Self-Rating Depression Scale (SDS) questionnaires. Results: There was a considerable difference in visual acuity as logarithm of the minimum angle of resolution (logMAR) between the patient and control groups (1.16 +/- 0.97 and 0.04 +/- 0.05 logMAR, respectively, p0.0001). Both PHQ-9 and SDS scores differed significantly between the two groups (10.18 +/- 4.68 and 8.07 +/- 4.90, p=0.04; and 47.94 +/- 12.56 and 39.91 +/- 8.80, p=0.004, respectively). Scores appeared to be positively correlated with logMAR visual acuity (Spearman rho=0.700, p0.0001 for PHQ-9; and 0.767, p0.0001 for SDS), and they were also correlated to each other (Spearman rho=0.759, p0.0001). Conclusion: Patients with CM having undergone proton beam therapy seem to be more depressed compared to a sample of healthy individuals, and the level of depression is correlated with their visual acuity.
机译：目的：确定用质子束放射治疗的脉络膜瘤（CM）患者抑郁症。患者及方法：这是一个横截面研究，包括50例患有50例患者（50％雄性，平均年龄= 49.88 + 6.34岁）和46岁和性爱匹配的健康对照（52％的男性，平均年龄= 48.60 +/- 8.05年）。参与者完成了患者健康问卷-9（PHQ-9）和Zung自评抑郁症（SDS）问卷。结果：视力相当差异，作为患者和对照组分辨率（Logmar）的最小角度的对数（1.16 +/- 0.97和0.04 +/- 0.05 Logmar，P <0.0001）。 PHQ-9和SDS分数都在两组之间显着不同（10.18 +/- 4.68和8.07 +/- 4.90，P = 0.04;和47.94 +/- 12.56和39.91 +/- 8.80，P = 0.004分别）。得分似乎与Logmar视力正相关（Spearman Rho = 0.700，P <0.0001; SDS的0.767，P <0.0001），它们也与彼此相关（Spearman Rho = 0.759，P＆ 0.0001）。结论：与健康个体样品相比，具有经过质子束治疗的CM的患者似乎更抑制，并且抑郁水平与它们的视力相关。

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