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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Transcriptomic Analysis of Histone Methyltransferase Setd7 Knockdown and Phenethyl Isothiocyanate in Human Prostate Cancer Cells
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Transcriptomic Analysis of Histone Methyltransferase Setd7 Knockdown and Phenethyl Isothiocyanate in Human Prostate Cancer Cells

机译：组蛋白甲基转移酶SetD7敲低的转录组分析及人前列腺癌细胞中的苯硫氰酸酯

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Background/Aim: Transcriptomic analysis was performed to evaluate the differential gene expression profiles of Setd7 knockdown (KD) and the effects of phenethyl isothiocyanate (PEITC) in human prostate cancer (PCa) LNCaP cells. Materials and Methods: RNA isolated from wild-type and Setd7-KD LNCaP cells in the presence or absence of PEITC was subjected to microarray analysis followed by Ingenuity (R) Pathway Analysis (IPA). Results: Setd7 KD impacted a larger set of genes and caused a higher fold change compared to PEITC treatment. Several signaling pathways were altered particularly inflammation-related TNFR signaling and PTEN/PI3K/AKT signaling by Setd7 KD and PEITC. Interestingly, PEITC and Setd7 KD at a small subset of genes that could be potential molecular targets. Conclusion: This study offers new insights into the mechanisms of action of the epigenetic modifier Setd7 and the effects of PEITC treatment in PCa cells and enhances our understanding of the potential cancer preventive/treatment effects of isothiocyanate compounds such as PEITC in PCa.
机译：背景/目的：进行转录组分析以评估SetD7敲低（KD）的差异基因表达谱和苯乙基异硫氰酸酯（PEITC）在人前列腺癌（PCA）LNCAP细胞中的作用。材料和方法：从野生型和SETD7-KD LNCAP细胞中分离的RNA在PEICC的情况下进行微阵列分析，然后是indenual（R）途径分析（IPA）。结果：SetD7 KD影响了较大一组基因，与PEITC治疗相比，较高的折叠变化。通过SetD7 KD和PEITC改变了几种与炎症相关的TNFR信号传导和PTEN / PI3K / AKT信号传导。有趣的是，PEITC和SETD7 KD在一个可能是潜在的分子靶标的基因的一小部分。结论：本研究提供了新的见解，进入表观遗传改性剂SETD7的作用机制以及PEITC治疗在PCA细胞中的影响，并提高了我们对异硫氰酸异氰酸酯化合物如PEDC中的潜在癌症预防/治疗作用的理解。

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