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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Radiotherapy Plus Total Androgen Block Versus Radiotherapy Plus LHRH Analog Monotherapy for Non-metastatic Prostate Cancer
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Radiotherapy Plus Total Androgen Block Versus Radiotherapy Plus LHRH Analog Monotherapy for Non-metastatic Prostate Cancer

机译：放射疗法加上总雄激素嵌段与放射治疗加上LHRH模拟单药治疗非转移前列腺癌

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Background/Aim: Patients with locally advanced prostate cancer are generally treated with radiotherapy (RT) which can be combined with hormonal therapy. RT plus monotherapy with luteinizing hormone-releasing hormone (LHRH) analog triptorelin was compared to RT plus total androgen block (TAB). Patients and Methods: A retrospective study was carried out on patients with locally advanced prostate cancer comparing RT plus monotherapy versus RT plus TAB. Results: For overall survival, no differences between patients receiving RT with monotherapy and those treated with TAB were observed. A trend favoring use of TAB was found for progression free survival. No differences in late gastrointestinal and genitourinary toxicities were reported. Conclusion: This study suggests that monotherapy with LHRH is as effective as TAB, which is important in selecting appropriate treatment considering that TAB can have higher risks of adverse events and reduce the quality of life of patients.
机译：背景/目的：局部晚期前列腺癌的患者通常用放射疗法（RT）治疗，可与激素治疗组合。 将单疗法加上培氏素激素释放激素（LHRH）模拟曲素蛋白与RT加上全雄激素嵌段（突出基）进行比较。 患者及方法：对局部晚期前列腺癌的患者进行了回顾性研究，比较RT加上RT加上RT Plus标签。 结果：对于整体存活，观察患者患者与单药治疗的患者没有差异，并观察到用标签处理的患者。 发现了有利于使用标签的趋势为进展免费生存。 报道了晚期胃肠和泌尿毒性没有差异。 结论：本研究表明，与LHRH的单一疗法与选项卡一样有效，这对于选择适当的治疗方案很重要，考虑到该标签可能具有更高的不良事件风险并降低患者的生活质量。

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