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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Preoperative Pulmonary Function Tests (PFTs) and Outcomes from Resected Early Stage Non-small Cell Lung Cancer (NSCLC)
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Preoperative Pulmonary Function Tests (PFTs) and Outcomes from Resected Early Stage Non-small Cell Lung Cancer (NSCLC)

机译：切除早期非小细胞肺癌（NSCLC）的术前肺功能测试（PFT）和结果

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Background: Preoperative pulmonary function tests (PFTs) predict operative morbidity and mortality after resection in lung cancer. However, the impact of preoperative PFTs on overall outcomes in surgically-resected stage I and II non-small cell lung cancer (NSCLC) has not been well studied. Patients and Methods: This is a retrospective study of 149 patients who underwent surgical resection as first-line treatment for stage I and II NSCLC at a single center between 2003 and 2014. PFTs [forced expiratory volume in 1 sec (FEV1), Diffusing Capacity (DLCO)] , both absolute values and percent predicted values were categorized into quartiles. The Kaplan-Meier method and Cox regression analysis were used to determine whether PFTs predicted for overall survival (OS). Logistic regression was used to estimate the risk of postoperative complications and length of stay (LOS) greater than 10 days based on the results of PFTs. Results: The median age of the cohort was 68 years. The cohort was predominantly males (98.6%), current or exsmokers (98%), with stage I NSCLC (82.76%). The majority of patients underwent a lobectomy (n=121, 81.21%). The predominant tumor histology was adenocarcinoma (n=70, 47%) followed by squamous cell carcinoma (n=61, 41%). The median follow-up of surviving patients was 53.2 months. DLCO was found to be a significant predictor of OS (HR=0.93, 95% CI=0.87-0.99; p=0.03) on univariate analysis. Although PFTs did not predict for postoperative complications, worse PFTs were significant predictors of length of stay 10 days. Conclusion: Preoperative PFTs did not predict for survival from resected early-stage NSCLC, but did predict for prolonged hospital stay following surgery.
机译：背景：术前肺功能试验（PFT）预测肺癌切除后的疗效发病率和死亡率。然而，术前PFT对外科阶段I和II非小细胞肺癌（NSCLC）的整体结果的影响尚未得到很好的研究。患者及方法：这是对2003年至2014年间单一中心的一级阶段I和II NSCLC进行手术切除的149名患者的回顾性研究.PFT [强迫呼气量（FEV1），扩散能力（DLCO）]，绝对值和预测值的百分比被分为四分位数。 KAPLAN-MEIER方法和COX回归分析用于确定是否预测总存活（OS）的PFT。 Logistic回归用于估计术后并发症和逗留程度的风险，并且基于PFT的结果大于10天。结果：队列中位年龄为68岁。队列主要是雄性（98.6％），电流或exsmokers（98％），I阶段NSCLC（82.76％）。大多数患者接受了肺叶切除术（n = 121,81.21％）。主要的肿瘤组织学是腺癌（n = 70,47％），然后是鳞状细胞癌（n = 61,41％）。存活患者的中位随访时间为53.2个月。 DLCO被发现是OS的显着预测因子（HR = 0.93,95％CI = 0.87-0.99; P = 0.03）。虽然PFT没有预测术后并发症，但PFT差是逗留时间的显着预测因子，而GT则为10天。结论：术前PFT未预测切除早期NSCLC的生存，但确实预测手术后长期住院住院。

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