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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >MicroRNA-107 Targets IKBKG and Sensitizes A549 Cells to Parthenolide
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MicroRNA-107 Targets IKBKG and Sensitizes A549 Cells to Parthenolide

机译：microRNA-107靶向IKBKG并使A549细胞敏感至嘌呤醇醚

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Background/Aim: Patients with advanced non-small cell lung cancer (NSCLC) frequently face a dismal prognosis because of lack of curative therapies. We, therefore, conducted a preclinical investigation of the therapeutic efficacy of microRNA-107 (miR-107). Materials and Methods: The effects of miR-107 on cell proliferation and target gene expression were studied. Combinatorial effects of miR-107 and parthenolide were evaluated. Results: Cell proliferation was repressed in A549 NSCLC cells transfected with miR-107. Inhibitor of nuclear factor kappa B kinase subunit gamma was directly targeted by miR-107. Overexpression of miR-107 in A549 cells sensitized them to parthenolide along with a marked reduction of cyclin-dependent kinase 2. Conclusion: Our findings unveil an important biological function of miR-107 in regulating lung cancer cell proliferation and elevating an antiproliferative effect of parthenolide on lung cancer cells, suggesting that miR-107 could be beneficial benefit treatment for advanced NSCLC.
机译：背景/目的：具有晚期非小细胞肺癌（NSCLC）的患者由于缺乏治疗疗法，经常面临令人沮丧的预后。因此，我们对MicroRNA-107（miR-107）的治疗效果进行了临床前调查。研究了MIR-107对细胞增殖和靶基因表达的影响。评价miR-107和阳离子醇的组合效应。结果：在用miR-107转染的A549 NSCLC细胞中抑制细胞增殖。核因子Kappa B激酶亚单位γ的抑制剂直接靶向miR-107。在A549细胞中的miR-107的过度表达致致嘌呤化合物的致嘌呤化合物的敏感性依赖性激酶2.结论：我们的研究结果揭示了MiR-107的重要生物学功能在调节肺癌细胞增殖中，并提高静血剂的抗增殖作用在肺癌细胞上，表明MIR-107可能是高级NSCLC的有益效益处理。

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