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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Application of Albumin-embedded Magnetic Nanoheaters for Release of Etoposide in Integrated Chemotherapy and Hyperthermia of U87-MG Glioma Cells
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Application of Albumin-embedded Magnetic Nanoheaters for Release of Etoposide in Integrated Chemotherapy and Hyperthermia of U87-MG Glioma Cells

机译：白蛋白嵌入式磁性纳米肽在烯丙糖苷释放中的应用及U87-Mg胶质瘤细胞中热疗的应用

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Background/Aim: Malignant gliomas remain refractory to several therapeutic approaches and the requirement for novel treatment modalities is critical to combat this disease. Etoposide is a topoisomerase-II inhibitor, which promotes DNA damage and apoptosis of cancer cells. In this study, we prepared albumin with embedded magnetic nanoparticles and etoposide for in vitro evaluation of combined hyperthermia and chemotherapy. Material and Methods: Magnetic nanoparticles were prepared by a modified co-precipitation method in the presence of human serum albumin and etoposide. A cellular proliferation assay was used to determine the effects of these nanostructures on the viability of U87 glioma cells in an alternating magnetic field. Results: The in vitro experiments showed that cell viability decreased to 59.4% after heat treatment alone and to 53.8% on that with free etoposide, while combined treatment resulted in 7.8% cell viability. Conclusion: Integrating hyperthermia and chemotherapy using albumin co-embedded magnetic nanoheaters and etoposide may represent a promising therapeutic option for glioblastoma.
机译：背景/目的：恶性胶质瘤仍然对几种治疗方法难以令人难以忍受，并且新的治疗方式的要求对于打击这种疾病至关重要。依托钠是拓扑异构酶-II抑制剂，其促进DNA损伤和癌细胞的凋亡。在这项研究中，我们制备了具有嵌入的磁性纳米粒子和依托磷脂的白蛋白，用于体外评估组合热疗和化疗。材料和方法：通过在人血清白蛋白和依托泊苷的存在下通过改性的共沉淀法制备磁性纳米粒子。细胞增殖测定用于确定这些纳米结构对交替磁场中U87胶质瘤细胞的活力的影响。结果：体外实验表明，单独热处理后，细胞活力降至59.4％，与游离依托泊苷的53.8％，同时组合处理导致细胞活力7.8％。结论：使用白蛋白共嵌入磁性纳米肽和依托泊苷的全聚热性和化疗可以代表胶质母细胞瘤的有希望的治疗选择。

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