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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Particle Stability During Pressurized Intra-peritoneal Aerosol Chemotherapy (PIPAC)
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Particle Stability During Pressurized Intra-peritoneal Aerosol Chemotherapy (PIPAC)

机译：加压内腹膜气溶胶化疗（PIPAC）的颗粒稳定性

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Background/Aim: Pressurized intra-peritoneal aerosol chemotherapy (PIPAC) is a new approach in the treatment of peritoneal carcinomatosis. With PIPAC currently limited to liquid chemotherapeutic solutions, this study aims to investigate whether the application range may be extended to the delivery of therapeutic nano- or microparticles. Materials and Methods: Human serum, bacteria cultures and macrophage cells were aerosolized in an established ex vivo model. Human serum composition was analyzed via gel electrophoresis. The viability of bacteria and macrophage cells was measured prior to and following PIPAC. Results: No structural disintegration of the plasma solution was detected. While the concentration and viability of Escherichia coli and Salmonella Enteritidis did not significantly change following aerosol formation, macrophage cells showed structural disintegration. Conclusion: Our ex vivo data suggest that PIPAC can be used to deliver complex particles. The delivery of small and less complex particles was feasible, yet the mechanical and physical properties of PIPAC might alter the stability of larger and more complex particles.
机译：背景/目的：加压腹膜内气溶胶化疗（PIPAC）是一种治疗腹膜癌症的新方法。利用PIPAC目前仅限于液体化学治疗溶液，本研究旨在研究施加范围是否可以扩展到治疗纳米或微粒的递送。材料和方法：人血清，细菌培养和巨噬细胞在已建立的离体模型中雾化。通过凝胶电泳分析人血清组合物。在PIPAC之前和之后测量细菌和巨噬细胞的活力。结果：检测到血浆溶液的结构崩解。虽然大肠杆菌和沙门氏菌的浓度和活力在气溶胶形成后没有显着改变，但巨噬细胞显示结构崩解。结论：我们的前体内数据表明PIPAC可用于提供复杂的颗粒。递送小而较差的颗粒是可行的，但PIPAC的机械和物理性质可能改变较大更复杂颗粒的稳定性。

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