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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Quality of Life Following Stereotactic Body Radiotherapy Versus Three-Dimensional Conformal Radiotherapy for Vertebral Metastases: Secondary Analysis of an Exploratory Phase II Randomized Trial
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Quality of Life Following Stereotactic Body Radiotherapy Versus Three-Dimensional Conformal Radiotherapy for Vertebral Metastases: Secondary Analysis of an Exploratory Phase II Randomized Trial

机译：立体定向体放射治疗与椎体转移的三维保形放疗后的生活质量：探索性期II型随机试验的二次分析

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Background/Aim: This was a prespecified secondary analysis of a randomized trial, which analyzed quality of life (QOL), fatigue, and emotional distress following stereotactic body radiotherapy (SBRT) versus conventional three-dimensional conformal radiotherapy (3DCRT) as part of palliative management of painful spinal metastases. Materials and Methods: Fifty-five patients were enrolled in this single-institutional randomized exploratory phase II trial (NCT02358720). Participants were randomly assigned to receive SBRT (single-fraction24 Gy) or 3DCRT (30 Gy/10 fractions). QOL (EORTC QLQ-BM22), fatigue (EORTC QLQ FA13), and emotional distress (QSC-R10) at the end of radiotherapy, along with 3- and 6-month followup were assessed. Results: At all recorded time points, there were no significant QOL differences between cohorts, including painful sites, pain characteristics, functional impairment, or psychosocial aspects (p0.05 for all). There were also no differences in all dimensions of fatigue between groups at each recorded time point (p0.05 for all). Emotional distress was also similar at three (p=0.248) and six months (p=0.603). Conclusion: Although these results demonstrate that SBRT does not cause worse QOL deteriorations compared to 3DCRT, larger randomized investigations are recommended to corroborate these findings.
机译：背景/目的：这是一项随机试验的预先确定的二级分析，分析了立体定向体放射治疗（SBRT）与常规三维保形放疗（3DCRT）之后的寿位身体放射疗法（SBRT）的寿命（QOL），疲劳和情绪困扰的质量。痛苦脊髓转移的管理。材料和方法：第五十五名患者注册了该单机构随机探索期二期试验（NCT02358720）。随机分配参与者接收SBRT（单级分24 GY）或3DCRT（30 Gy / 10分数）。 QOL（EORTC QLQ-BM22），疲劳（EORTC QLQ-BM22）和放疗结束时的情绪窘迫（QSC-R10）以及3个月和6个月的跟随进行了评估。结果：在所有录制的时间点，群组之间没有显着的QoL差异，包括痛苦的部位，疼痛特征，功能障碍或心理社会方面（P＆GT; 0.05）。在每个记录的时间点（P＆GT为0.05）之间的组之间疲劳的所有疲劳尺寸也没有差异。情绪困扰在三个（p = 0.248）和六个月中也相似（p = 0.603）。结论：尽管与3DCRT相比，这些结果表明SBRT不会导致较差的QOL劣化，建议较大的随机调查来证实这些发现。

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