...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Impact of COX2 Inhibitor for Regulation of PD-L1 Expression in Non-small Cell Lung Cancer
【24h】

Impact of COX2 Inhibitor for Regulation of PD-L1 Expression in Non-small Cell Lung Cancer

机译：COX2抑制剂对非小细胞肺癌PD-L1表达调控的影响

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background/Aim: There is no clear evidence in the literature regarding the regulation of programmed cell death-ligand 1 (PD-L1) expression by cyclo-oxygenase-2 (COX2). In this study, whether PD-L1 expression was regulated by COX2 activity was examined in vitro. Materials and Methods: Resected lung cancer specimens were analyzed for PD-L1 and COX2 expression by immunohistochemical analysis. Next, co-localization of PD-L1 and COX2 expression was analyzed by double-fluorescence staining. Lastly, the effect of COX2 inhibition on the expression of PD-L1 was examined using lung cancer cell lines. Results: PD-L1 expression was significantly correlated with COX2 expression in the resected specimens. The majority of cancer cells that expressed PD-L1 also co-expressed COX2. However, treatment of lung cancer cell lines with a COX2 inhibitor had no impact on PD-L1 expression. Conclusion: Our results suggest that COX2 inhibition might have no effect on the usage of immune checkpoint inhibitors in lung cancer treatment.
机译：背景/目的：通过环氧氧酶-2（COX2）的编程细胞死亡 - 配体1（PD-L1）表达的调节有明确的证据。在该研究中，在体外检查COX2活性是否调节PD-L1表达。材料和方法：通过免疫组化分析对PD-L1和COX2表达分析切除的肺癌标本。接下来，通过双荧光染色分析PD-L1和COX2表达的共定位。最后，使用肺癌细胞系检查了COX2抑制对PD-L1表达的影响。结果：PD-L1表达与切除试样中的COX2表达明显相关。表达PD-L1的大多数癌细胞也共同表达了COX2。然而，用COX2抑制剂治疗肺癌细胞系对PD-L1表达没有影响。结论：我们的研究结果表明，COX2抑制可能对肺癌治疗中免疫检查点抑制剂的用途没有影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号