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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Primary Tumor Size Predicts Distant Metastasis of Mucosal Malignant Melanoma in Head and Neck
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Primary Tumor Size Predicts Distant Metastasis of Mucosal Malignant Melanoma in Head and Neck

机译：原发性肿瘤大小预测头部和颈部粘膜恶性黑素瘤的远端转移

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Background/Aim: To investigate the possible association between primary tumor size and overall survival and/or distant metastasis-free survival of patients with mucosal malignant melanoma of the head and neck. Patients and Methods: A total of 25 patients that have had primary tumor resection were enrolled in this study. Primary tumor size was assessed as the maximum size of the primary tumor in pathological and surgical reports. Results: Patients with a primary tumor size of = 43 mm showed a significant association with shorter overall survival (p=0.007) and distant metastasis-free survival (p=0.005) by the log-rank test. Multivariate survival analyses of two Cox's hazards proportional models showed that, in model1, pT4a-4b (p=0.01) and primary tumor size = 43 mm (p=0.03) were significantly associated with shorter overall survival, and primary tumor size = 43 mm (p=0.02) was significantly associated with shorter distant metastasis-free survival. In model2, pStage IVA-IVB (p=0.02) and primary tumor size = 43 mm (p=0.03) were significantly associated with shorter overall survival, and primary tumor size = 43 mm (p=0.02) was significantly associated with shorter distant metastasis-free survival. Conclusion: Large tumor size (= 43 mm) is a predictor of shorter overall survival and distant metastasis-free survival after primary tumor resection of mucosal malignant melanoma of the head and neck.
机译：背景/目的：研究头部和颈部粘膜恶性黑素瘤的患者的原发性肿瘤大小和整体存活和/或远处转移存活之间的可能关联。患者和方法：本研究中共有25名患有原发性肿瘤切除的患者。将原发性肿瘤大小评估为病理和手术报告中原发性肿瘤的最大尺寸。结果：＆gt的主要肿瘤大小的患者＆ = 43mm显示出通过对数级试验的较短总存活（p = 0.007）和远处转移存活（p = 0.005）显着关联。两种Cox危险的多变量存活分析比例模型显示，在模型1中，Pt4a-4b（p = 0.01）和原发性肿瘤大小＆ = 43 mm（p = 0.03）显着与较短的整体存活和原发性肿瘤大小和gt ; = 43mm（p = 0.02）与无远相转移存活率显着相关。在模型2中，Pstage IVA-IVB（P = 0.02）和原发性肿瘤大小＆ = 43mm（p = 0.03）显着与较短的总存活率相关，原发性肿瘤大小＆ = 43mm（p = 0.02）显着显着与较短的远端转移生存相关。结论：大肿瘤大小（＆ = 43mm）是粘膜恶性黑素瘤的原发性肿瘤切除后的较短整体存活和远处转移存活的预测因子。

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