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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Elevated Neutrophil-to-Lymphocyte-ratio and Platelet-to-Lymphocyte Ratio in Myelofibrosis: Inflammatory Biomarkers or Representatives of Myeloproliferation Itself?
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Elevated Neutrophil-to-Lymphocyte-ratio and Platelet-to-Lymphocyte Ratio in Myelofibrosis: Inflammatory Biomarkers or Representatives of Myeloproliferation Itself?

机译：髓细胞中的中性粒细胞至淋巴细胞 - 比率升高，血小板到淋巴细胞比例：炎症生物标志物或野鸭本身代表？

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Background/Aim: We aimed to investigate clinical associations of inflammatory biomarkers neutrophil-tolymphocyte-ratio (NLR) and platelet-to-lymphocyte-ratio (PLR) in patients with myelofibrosis, myeloproliferative neoplasm with inflammatory background. Patients and Methods: We retrospectively analyzed a cohort of 102 myelofibrosis patients. NLR and PLR were assessed in addition to other disease-specific parameters. Results: NLR and PLR were significantly higher in myelofibrosis than in healthy controls. Higher NLR was significantly associated with Janus-kinase-2 (JAK2)-mutation, wild-type-Calreticulin (CALR), older age and parameters reflecting increased proliferative potential of disease (higher leukocytes, higher hemoglobin, larger spleensize), whereas there was no significant association with C-reactive-protein (CRP). Higher PLR was significantly associated with absence of blast-phase-disease, absence of constitutional-symptoms, lower percentage-of-circulatoryblasts, smaller spleen-size and lower CRP. In the Coxregression-model, higher-NLR (HR=2.76; p=0.004), lower-PLR (HR=1.99; p=0.042) and Dynamic-International-Prognostic-System (DIPSS) (HR=3.26; p0.001) predicted inferior survival independently of each other. Conclusion: In the context of myelofibrosis, elevated NLR and PLR are more likely to represent myeloproliferation itself and not necessary the extent of inflammation.
机译：背景/目的：我们旨在调查炎症生物标志物中性粒细胞 - 甲状腺细胞 - 比（NLR）和血小板到淋巴细胞 - 比（PLR）的临床关联，在肌肌纤维化症患者中，肌蜂蜜瘤与炎症背景。患者和方法：我们回顾性分析了102例肌纤维化患者的队列。除其他疾病特异性参数外，还评估了NLR和PLR。结果：髓纤维化的NLR和PLR显着高于健康对照。较高的NLR与Janus-Kinase-2（JAK2） - utiggation，野生型钙素（Calr），较老年和参数，反映疾病增殖潜力增加（较高白细胞，血红蛋白，较大的萎缩），较高的年龄和参数与C-反应蛋白（CRP）无明显关联。较高的PLR显着与缺乏血液疾病的缺乏有关，没有构成症状，较低的循环细胞百分比，较小的脾脏大小和降低CRP。在Coxregression-Model中，高NLR（HR = 2.76; P = 0.004），下PLR（HR = 1.99; P = 0.042）和动态国际预测系统​​（倾枝）（HR = 3.26; P <0.001 ）预测彼此独立的劣质生存。结论：在骨髓纤维化的背景下，升高的NLR和PLR更有可能代表凹凸本身，而不是必需的炎症程度。

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