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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Genomic Instability in Buccal Mucosal Cells of Municipal Street Sweepers as Evaluated by Micronucleus Test
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Genomic Instability in Buccal Mucosal Cells of Municipal Street Sweepers as Evaluated by Micronucleus Test

机译：微核试验评估的市政街道扫掠的颊粘膜细胞中的基因组不稳定性

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Background/Aim: Since street sweepers comprises a group of workers who are in daily contact with rubbish, dust and air pollution, the aim of this study was to evaluate potential cytotoxic and mutagenic effects in buccal mucosa cells of street sweepers. Materials and Methods: A total of 20 male street sweepers aged from 22 to 56 years were included in the experimental group. A total of 20 men matched by age were used as the control group. Cytotoxicity and mutagenicity were analyzed by micronucleus test in buccal mucosal cells. Results: Statistically significant differences (p0.05) in the frequency of micronuclei was detected in the street sweepers when compared to the control group. No remarkable differences were found to other metanuclear alterations indicative for cytotoxicity such as pyknosis, karyolysis, and karryorhexis when compared to matched controls. Conclusion: Taken together, our results indicate that street sweepers comprise an at-risk group as a result of increased mutagenicity found to buccal mucosa cells.
机译：背景/宗旨：街头扫地机包括一群人每天与垃圾，尘埃和空气污染接触的工人，这项研究的目的是评估街头扫掠的口腔粘膜细胞中的潜在细胞毒性和致突变性。材料和方法：在实验组中包含22至56岁的20名男性街道扫地机。共有20名符合年龄的男性被用作对照组。通过颊粘膜细胞中的微核试验分析细胞毒性和致突变性。结果：与对照组相比，在街道扫描中检测到微核频率的统计学显着差异（P <0.05）。与匹配的对照相比，没有发现表明细胞毒性等细胞毒性的其他核核改动的差异显着差异。结论：在一起，我们的结果表明，由于对颊粘膜细胞的诱变程度增加，街道扫描剂包括抗风险组。

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