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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Predictors for High Microsatellite Instability in Patients with Colorectal Cancer Fulfilling the Revised Bethesda Guidelines
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Predictors for High Microsatellite Instability in Patients with Colorectal Cancer Fulfilling the Revised Bethesda Guidelines

机译：结直肠癌患者高幼苗不稳定性的预测因子，达到修订的贝塞斯达指南

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Background: The revised Bethesda guidelines (rBG) are generally used for screening of Lynch syndrome, and few researchers have investigated the associations between microsatellite instability (MSI) status and each item of the rBG. Patients and Methods: This retrospective study included patients with colorectal cancer who were classified into those fulfilling the rBG (Bethesda group) and those not (control group). The breakdown of each item in the rBG and predictors of high MSI (MSI-H) were determined in the Bethesda group. Results: Of 809 consecutive patients, 161 (19.9%) were found to fulfil the rBG criteria. As a predictor of MSI-H, items 2 or 5 of the rBG showed a sensitivity of 93.3%. Item 5 and right-sided tumour location were independent predictors of MSI-H in patients fulfilling the rBG (odds ratio(OR)=4.49 and 25.1; p=0.0260 and 0.0001, respectively). Conclusion: Item 5 of the rBG and right-sided tumour location are significant predictors of MSI-H.
机译：背景：修订后的Bethesda指南（RBG）通常用于筛选林奇综合征，并且很少有研究人员已经调查了微卫星不稳定性（MSI）状态和RBG的每个项目之间的关联。 患者和方法：该回顾性研究包括结直肠癌的患者分为满足RBG（Bethesda组）和那些（对照组）的患者。 在Bethesda组中测定RBG和高MSI（MSI-H）中的每个项目的崩溃和预测器。 结果：809例连续患者，发现161名（19.9％）达到RBG标准。 作为MSI-H的预测因子，RBG的项目2或5显示敏感性为93.3％。 第5项和右侧肿瘤位置是满足RBG的患者的MSI-H独立预测因子（差异比（或）= 4.49和25.1; P = 0.0260和<0.0001）。 结论：RBG和右侧肿瘤位置的第5项是MSI-H的显着预测因子。

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