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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >A Retrospective Analysis of Ki-67 Index and its Prognostic Significance in Over 800 Primary Breast Cancer Cases
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A Retrospective Analysis of Ki-67 Index and its Prognostic Significance in Over 800 Primary Breast Cancer Cases

机译：ki-67指标的回顾性分析及其在800多种主要乳腺癌病例中的预后意义

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Background/Aim: The Ki-67 index is chiefly important for distinguishing between luminal A and luminal B human epidermal growth factor receptor 2 (HER2neu)negative breast cancer subtypes. However, its ability to predict response to chemotherapy is uncertain. Patients and Methods: Patients treated for primary breast cancer at the University Hospital of Cologne were identified. Immunohistochemistry for Ki-67 detection was performed according to standard protocols. Kaplan-Meier survival curves were calculated and compared using the log-rank test. Results: Patients with low Ki-67 index had a significantly better disease-free-survival (DFS) than patients with high Ki-67 index (hazard ratio=2.85; 95% confidence interval=1.45-5.59; p=0.002). A significant influence on DFS was demonstrated (hazard ratio(HR)=1.02; confidence interval(CI)=1.00-1.04; p=0.048) within the subgroup of hormone receptor-positive and HER2neu-negative patients, but not within the subgroup of those with luminal B/HER2neu-negative tumors (DFS: p=0.801; overall-survival: p=0.379). Conclusion: The Ki-67 index has a prognostic impact on DFS in patients with hormone receptor-positive and HER2neu-negative tumors. The strict cut-off value was not suitable for distinguishing between high-and low-risk patients and their response to adjuvant chemotherapy.
机译：背景/目的：KI-67指数主要是区分Luminal A和Luminal B人表皮生长因子受体2（Her2neu）阴性乳腺癌亚型的重要性。然而，它预测化疗反应的能力是不确定的。患者和方法：鉴定了科隆大学医院治疗原发性乳腺癌的患者。根据标准方案进行KI-67检测的免疫组织化学。计算并使用日志秩检验计算Kaplan-Meier生存曲线。结果：低KI-67指数的患者比高KI-67指数（危害比率= 2.85; 95％置信区间= 1.45-5.59; p = 0.002），患者具有明显更好的疾病生存（DFS）。对DFS的显着影响（危害比（HR）= 1.02;置信区间（CI）= 1.00-1.04; p = 0.048），但不在亚组内那些患有腔B / HER2NEU阴性肿瘤的人（DFS：P = 0.801;总体存活：P = 0.379）。结论：KI-67指数对激素受体阳性和HER2NEU阴性肿瘤患者的DFS对DFS具有预后的预后影响。严格的截止值不适合区分高低危患者及其对佐剂化疗的反应。

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