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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Identifying Rational Candidates for Immunotherapy Targeting PD-1/PD-L1 in Cervical Cancer
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Identifying Rational Candidates for Immunotherapy Targeting PD-1/PD-L1 in Cervical Cancer

机译：鉴定宫颈癌中的免疫疗法的理性候选者靶向PD-1 / PD-L1

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Background/Aim: To investigate the abundance of programmed death-ligand 1 (PD-L1) expression and identify rational candidates for anti-PD-1/PD-L1 immunotherapies in cervical cancer. Patients and Methods: In 27 patients with FIGO stage IB1-IIA cervical cancer, paraffin-embedded tumors were immunohistochemically stained with PD-L1 antibody. The correlation of tumoral PD-L1 expression with clinicopathological factors and survival outcomes were evaluated. Results: Overall, PD-L1 expression was primarily detected in 12 (44.4%) patients. All tumors with PD-L1 expression were squamous cell carcinomas (SqCC). In subgroup analysis of SqCC, higher PD-L1 expression was associated with low preoperative serum SqCC antigen level (p= 0.030) and no parametrial invasion (p= 0.048). The 5-year progression-free survival (83.3% vs. 50.0%. p= 0.136) and overall survival rates (90.9% vs. 83.3%, p= 0.615) were superior in patients with PD-L1 expression that in those without PD-L1 expression; however, neither was significant. Conclusion: Patients with SqCC and favorable clinicopathological factors could be candidates for anti-PD-1/PD-L1 immunotherapy in cervical cancer.
机译：背景/目的：研究编程死亡 - 配体1（PD-L1）表达的丰度，并鉴定宫颈癌中的抗PD-1 / PD-L1免疫治疗的理性候选者。患者和方法：在27例Figo阶段IB1-Iia宫颈癌患者中，用PD-L1抗体免疫染色石蜡包埋的肿瘤。评估了肿瘤PD-L1表达与临床病理因子和存活结果的相关性。结果：总体上，PD-L1表达主要在12名（44.4％）患者中检测。所有具有PD-L1表达的肿瘤都是鳞状细胞癌（SQCC）。在SQCC的亚组分析中，较高的PD-L1表达与低术前血清SQCC抗原水平有关（P = 0.030）并且没有参数侵袭（P = 0.048）。 5年的进展生存率（83.3％对50.0％。P = 0.136）和总存活率（90.9％与83.3％，p = 0.615）在没有PD的PD-L1表达的患者中优越-l1表达;但是，两者都没有重要。结论：SQCC和有利的临床病理因子患者可以是宫颈癌抗PD-1 / PD-L1免疫疗法的候选者。

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