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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >The Contribution of Matrix Metalloproteinase-7 Promoter Genotypes in Breast Cancer in Taiwan
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The Contribution of Matrix Metalloproteinase-7 Promoter Genotypes in Breast Cancer in Taiwan

机译：台湾乳腺癌中基质金属蛋白酶-7启动子基因型的贡献

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Background/Aim: The matrix metalloproteinase (MMP) family of enzymes are in charge of degradation of various components of the extracellular matrix and their functional genetic polymorphisms may be associated with cancer susceptibility. The functional polymorphisms in the promoter region of MMP7 (A-181G and C-153T) have been reported to influence the binding capacity of nuclear proteins and may contribute to genetic susceptibility to cancer. In this study, we focused on investigating the contribution of the genotypes of MMP7 (A-181G and C-153T) to breast cancer in Taiwan. Materials and Methods: These two polymorphisms were genotyped in 1,232 patients with breast cancer and 1,232 controls by polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The odds ratios (ORs) after adjusting for age, family history of cancer, smoking and alcohol drinking status for those carrying AG and GG genotypes at MMP7 promoter A-181G were 1.22 (95% CI=0.91-1.63, p=0.2235) and 2.84 (95% CI=1.64-7.48, p=0.0007) respectively, compared to those carrying the wild-type AA genotype. Supporting this finding, the adjusted OR for those carrying the G allele at MMP7 promoter A-181G was 1.57 (95% CI=1.29-1.93, p=0.0008), compared to those carrying the wild-type A allele. There was no polymorphic genotype at MMP7 C-153T found among any of the investigated individuals. Conclusion: Our findings suggest that the MMP7 A-181G polymorphisms may play a role in determining personal cancer susceptibility and GG genotype at MMP7 A-181G may serve as a biomarker for early detection and prediction of breast cancer in Taiwanese.
机译：背景/目的：基质金属蛋白酶（MMP）酶系列是细胞外基质的各种组分的降解，其功能遗传多态性可能与癌症易感性有关。据报道，MMP7（A-181G和C-153T）的启动子区域中的功能多态性以影响核蛋白的结合能力，并有助于癌症的遗传易感性。在这项研究中，我们专注于调查MMP7（A-181G和C-153T）基因型对台湾乳腺癌的贡献。材料和方法：通过聚合酶链反应限制片段长度多态性方法，在1,232名乳腺癌和1,232患者患者中基因分型进行了这些两种多态性。结果：调整年龄的差距（或），MMP7启动子A-181G的携带AG和GG基因型的年龄，癌症，吸烟和酒精饮酒状况的年龄，吸烟和酒精饮用状态为1.22（95％Ci = 0.91-1.63，P = 0.2235与携带野生型AA基因型的人相比，分别为2.84（95％CI = 1.64-7.48，p = 0.0007）。与那些携带野生型等位基因的人相比，支持该发现的该发现，调节或用于携带G等位基因的G等于G等级的那些方法1.57（95％CI = 1.29-1.93，P = 0.0008）。在任何研究的个体中发现MMP7 C-153T中没有多态性基因型。结论：我们的研究结果表明，MMP7 A-181G多态性可能在确定个人癌症易感性和MMP7 A-181G的GG基因型中发挥作用，可作为台湾人早期检测和预测乳腺癌的生物标志物。

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