...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Outcomes and Prognostic Factors of Resected Salivary Gland Malignancies: Examining a Single Institution's 12-year Experience
【24h】

Outcomes and Prognostic Factors of Resected Salivary Gland Malignancies: Examining a Single Institution's 12-year Experience

机译：切除唾液腺恶性肿瘤的结果和预后因素：检查单个机构的12年经验

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Despite adjuvant radiotherapy, survival outcomes remain poor in patients with salivary gland malignancies who have multiple poor prognostic factors. This study aimed to determine which patients may benefit from treatment intensification. Patients and Methods: Patients who underwent curative resection with or without adjuvant radiotherapy between 2002 and 2014 were identified and a retrospective chart review was performed. Overall survival (OS) and disease-free survival (DFS) were the main outcomes measured. Results: A total of 95 patients met the inclusion criteria. The median follow-up was 46.8 months. The median age was 60 years. Radiotherapy was given to 78 patients. Multivariate analysis revealed that male sex and perineural invasion significantly reduced overall and disease-free survival. Distant metastases comprised of 67% of recurrences and 33% were locoregional. Conclusion: Adjuvant chemoradiotherapy should be considered for patients with tumors with perineural invasion, especially in males with high-risk histopathology or high-grade, late-stage disease. To our knowledge, this is the first study to assess the impact of pack-year smoking history on survival outcomes.
机译：背景：尽管辅助放疗，患者患者患者仍然较差，唾液腺恶性肿瘤患者仍然较差，他们具有多重预后因素。本研究旨在确定哪些患者可能会受益于治疗强度。患者及方法：确定了2002年至2014年在2002年至2014年间的疗法放疗的疗效切除患者，并进行了回顾性图表审查。总存活（OS）和无病生存（DFS）是测量的主要结果。结果：共有95名患者达到纳入标准。中位后续行动为46.8个月。中位年龄为60年。放疗78例患者。多变量分析显示，男性性和麻省病变侵袭显着降低了整体和无病的存活率。含有67％的复发和33％的远端转移均为招生。结论：辅助化学疗法应考虑肿瘤患者的肿瘤患者，特别是患有高风险组织病理学或高档后期疾病的雄性。据我们所知，这是第一次评估包装减少吸烟史对生存结果影响的研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号