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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Gemini Cationic Amphiphiles Control Biofilm Formation by Bacterial Vaginosis Pathogens
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Gemini Cationic Amphiphiles Control Biofilm Formation by Bacterial Vaginosis Pathogens

机译：Gemini阳离子两亲控制通过细菌性阴道病病原体控制生物膜形成

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Antibiotic resistance and recurrence of bacterial vaginosis (BV), a polymicrobial infection, justify the need for novel antimicrobials to counteract microbial resistance to conventional antibiotics. Previously, two series of cationic amphiphiles (CAms) which self-assemble into supramolecular nanostructures with membrane-lytic properties were designed with hydrophilic head groups and nonpolar domains. The combination of CAms and commonly prescribed antibiotics is suggested as a promising strategy for targeting microorganisms that are resistant to conventional antibiotics. Activities of the CAms against Gardnerella vaginalis ATCC 14018, a representative BV pathogen, ranged from 1.1 to 24.4 mu M. Interestingly, the tested healthy Lactobacillus species, especially Lactobacillus plantarum ATCC 39268, were significantly more tolerant of CAms than the selected pathogens. In addition, CAms prevented biofilm formation at concentrations which did not influence the normal growth ability of G. vaginalis ATCC 14018. Furthermore, the biofilm minimum bactericidal concentration (MBC-Bs) of CAms against G. vaginalis ATCC 14018 ranged from 58.8 to 425.6 mu M, while much higher concentrations (>= 850 mu M) were required to produce >= 3-log reductions in the number of biofilm-associated lactobacilli. The conventional antibiotic metronidazole synergized strongly with all tested CAms against planktonic cells and biofilms of G. vaginalis ATCC 14018. The synergism between CAms and the tested conventional antibiotic may be considered a new, effective, and beneficial method of controlling biofilm-associated bacterial vaginosis.
机译：细菌性阴道病（BV）的抗生素抗性和复发，一种多发性化感染，证明了新型抗微生物的需要，以抵消对常规抗生素的微生物抗性。以前，使用亲水性头部和非极性结构域设计了自组装成具有膜 - 裂解性的超分子纳米结构的两系列阳离子两亲（凸轮）。凸轮和通常规定的抗生素的组合被认为是针对靶向常规抗生素的微生物的有希望的策略。对CAMS对Gardnerella阴道ATCC 14018的活动，代表性BV病原体，从1.1到24.4亩M.有趣的是，经过测试的健康乳酸杆菌物种，尤其是乳酸杆菌Plantarum ATCC 39268比选定的病原体显着更容许凸轮。此外，凸轮防止了在不影响G.阴道ATCC 14018的正常生长能力的浓度下的生物膜形成。此外，凸轮的生物膜最小杀菌浓度（MBC-BS）对阵G.阴道灭弧菌14018的范围为58.8至425.6μm M，虽然需要更高的浓度（> =850μm）来产生> = 3-伐地减少生物膜相关乳杆菌的数量。传统的抗生素甲硝唑强烈地用针对浮游细胞的所有测试凸轮和G.阴道ATCC 14018的生物膜强烈协同作用。凸轮和测试的常规抗生素之间的协同作用可以被认为是控制生物膜相关细菌性阴道病的新的，有效和有益的方法。

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