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首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Reprogramming of central carbon metabolism in cancer stem cells
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Reprogramming of central carbon metabolism in cancer stem cells

机译：癌症干细胞中央碳代谢的重新编程

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Cancer metabolism has been studied for years and adopted in the clinic for monitoring disease progression and therapy response. Despite our growing knowledge of a distinctly altered metabolic behavior in cancer, drugs targeting cancer metabolism have remained less than promising. Recent efforts in cancer stem cell (CSC) biology suggest that a subpopulation of tumor-initiating cells within the tumor bulk represents the root of tumor recurrence and therapy resistance. In recent years, metabolic phenotype of CSCs of various tumor types has been identified. This breakthrough has shed light on the underlying mechanism by which CSCs maintain stemness, confer resistance to therapies and initiate tumor relapse. The distinct metabolic characteristics of CSCs compared to non-CSCs provide an opportunity to target CSCs more specifically and have become a major focus in cancer research in recent years with substantial efforts conducted towards discovering clinical targets. This perspective article summarizes the current knowledge of CSC metabolism in carcinogenesis and highlights the potential of targeting CSC metabolism for therapy.
机译：已经研究了癌症代谢多年并在临床上采用，用于监测疾病进展和治疗反应。尽管我们越来越多地了解癌症中患者明显改变的代谢行为，但靶向癌症代谢的药物仍然不受承诺。最近癌症干细胞（CSC）生物学的努力表明肿瘤散装内的肿瘤引发细胞的亚群代表肿瘤复发和治疗抗性的根本。近年来，已经确定了各种肿瘤类型的CSC的代谢表型。这种突破在CSCs保持茎的潜在机制上阐明了潜在的机制，赋予疗法抵抗力并引发肿瘤复发。与非CSCs相比，CSCs的不同代谢特征为近年来近年来迄今为止，在临床目标中进行了大量努力，对近年来癌症研究的重大关注，提供了靶向CSC的机会。该透视文章总结了目前CSC代谢在致癌作用中的知识，并突出了靶向CSC代谢治疗的潜力。

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