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Using curcumin to turn the innate immune system against cancer

机译：使用姜黄素将先天免疫系统转化对抗癌症

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Curcumin has been at the center of vigorous research and major debate during the past decade. Inspired by its anti-inflammatory properties, many curcumin-based products are being sold now to manage various forms of arthritis. Parallel preclinical studies have established its role in dissolving beta-amyloid plaques, mu-based neurofibrillary tangles, and also alpha-synuclein-linked protein aggregates typically observed in Parkinson's disease. In cancer research, most cancer cells in culture are eliminated by curcumin at an IC50 of 15-30 mu M, whereas the maximum in vivo curcumin concentration achieved in humans is only about 6 mu M. Additionally, a decade ago, no improvement over the placebo groups was observed in clinical studies using free curcumin as an anticancer agent. The lack of anticancer efficacy was attributed to its low bioavailability, which results from the low water-solubility and high metabolic rate in vivo. Newer lipid-complexed or antibody-targeted forms have been used and these studies have revealed an exciting property of curcumin, which involves repolarization of the tumor-promoting, tumor-associated microglia/macrophages (TAMs) into a tumoricidal form and recruitment of natural killer cells from the periphery. This review will cover some efforts to explore the effect of appropriately-delivered curcumin to dramatically alter the tumor microenvironment, thereby launching an indirect attack on the tumor cells and the tumor stem cells. Reviewing some aspects of immunotherapy, this article will argue for the use of the innate immune cells in cancer therapy.
机译：姜黄素在过去十年中一直处于积极的研究和重大辩论的中心。灵感来自其抗炎特性，现在销售了许多姜黄素的产品来管理各种形式的关节炎。平行的临床前研究已经建立了溶解β-淀粉样斑块，尿基神经纤维缠结的作用，以及通常在帕金森病中观察到的α-突触核蛋白连接的蛋白质聚集体。在癌症研究中，培养中的大多数癌细胞在15-30μm的IC50下通过姜黄素消除，而人类达到的体内姜黄素浓度的最大值仅为6亩。另外，十年前，没有改善使用游离姜黄素作为抗癌剂在临床研究中观察到安慰剂组。缺乏抗癌疗效归因于其低生物利用度，这是由低水溶性和体内代谢率的降低。已经使用了较新的脂质复合物或抗体靶向形式，这些研究揭示了姜黄素的激动性，其涉及肿瘤促进，肿瘤相关的小胶质细胞/巨噬细胞（TAMS）的旋转性和自然杀伤的招募来自周边的细胞。本综述将介绍一些促进适当递送的姜黄素促进肿瘤微环境的效果的努力，从而在肿瘤细胞和肿瘤干细胞上发射间接攻击。审查免疫疗法的某些方面，本文将争辩使用癌症治疗中的先天免疫细胞。

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