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The role of hydrogen sulfide in cyclic nucleotide signaling

机译：硫化氢在循环核苷酸信号中的作用

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Hydrogen sulfide (H2S) is recognized as an endogenous gaseous transmitter alongside nitric oxide (NO) and carbon monoxide (CO). By integrating into multiple signaling pathways, H2S elicits biological functions in various mammalian systems. Among these pathways, cyclic nucleotide signaling has gradually gained attention in the past decade. Based on current evidence, it seems that H2S may differentially affect the activity of resting adenylyl cyclases (ACs) and activated ACs, therefore playing a dual role in the regulation of cyclic adenosine monophosphate (cAMP) mediated signaling. However, how H2S achieves the differential regulation on ACs remains unknown at molecular level. In the context of cyclic guanosine monophosphate (cGMP) regulation, H2S augments its downstream signaling at least through three different mechanisms: (1) H2S potentiates the response of soluble guanylyl cyclases (sGCs) to NO; (2) H2S inhibits activity of phosphodiesterases (PDEs); and (3) H2S enhances the production of NO. By regulating cyclic nucleotide signaling, H2S possesses therapeutic potentials particularly for hypertension and cardiac injury which have also been discussed in the current review. Nevertheless, a detailed portrayal of H2S mediated interaction with target proteins is still required for a better understanding of the role of this important gaseous mediator in regulating cyclic nucleotide signaling. (C) 2017 Elsevier Inc. All rights reserved.
机译：硫化氢（H2S）被鉴定为内源气态发射器，涉及一氧化氮（NO）和一氧化碳（CO）。通过集成到多个信号通路中，H2S在各种哺乳动物系统中引出生物学功能。在这些途径中，循环核苷酸信号传导在过去十年中逐渐受到关注。基于当前证据，H 2 S似乎可以差异地影响静止腺苷酸环酶（ACS）和活化ACs的活性，因此在循环腺苷单磷酸盐（CAMP）介导的信号传导的调节中发挥双重作用。然而，H2S如何实现ACS上的差异调节在分子水平上仍然未知。在循环鸟苷（CGMP）调节的背景下，H2S至少通过三种不同的机制增强其下游信号：（1）H2S增强可溶性观冠酶（SGCs）至NO的响应; （2）H 2 S抑制磷酸二酯酶（PDE）的活性; （3）H2S增强了NO的生产。通过调节循环核苷酸信号传导，H2S具有特别适用于当前审查中也讨论的高血压和心脏损伤的治疗潜力。然而，仍然需要对H 2 S介导的与靶蛋白的相互作用进行详细描述，以更好地理解该重要的气态介质在调节环状核苷酸信号传导中的作用。 （c）2017年Elsevier Inc.保留所有权利。

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