rRNA Methylation and Antibiotic Resistance

I. A. Osterman; O. A. Dontsova; P. V. Sergiev

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rRNA Methylation and Antibiotic Resistance

机译：rRNA甲基化和抗生素抗性

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Methylation of nucleotides in rRNA is one of the basic mechanisms of bacterial resistance to protein synthesis inhibitors. The genes for corresponding methyltransferases have been found in producer strains and clinical isolates of pathogenic bacteria. In some cases, rRNA methylation by housekeeping enzymes is, on the contrary, required for the action of antibiotics. The effects of rRNA modifications associated with antibiotic efficacy may be cooperative or mutually exclusive. Evolutionary relationships between the systems of rRNA modification by housekeeping enzymes and antibiotic resistance-related methyltransferases are of particular interest. In this review, we discuss the above topics in detail.

机译：rRNA中核苷酸的甲基化是对蛋白质合成抑制剂的细菌性抗性的基本机制之一。已经发现了相应甲基转移酶的基因在生产者菌株和致病性细菌的临床分离株中发现。在某些情况下，抗生素作用所需的内政酶的RRNA甲基化是相反的。与抗生素效能相关的RRNA修饰的影响可能是合作的或相互排斥的。通过家务酶和抗生素抗性相关甲基转移酶的RRNA改性系统之间的进化关系特别感兴趣。在本次审查中，我们详细讨论了上述主题。

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来源
《Biochemistry》 |2020年第11期|共15页
作者
I. A. Osterman; O. A. Dontsova; P. V. Sergiev;
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作者单位

Center of Life Sciences Skolkovo Institute of Science and Technology;

Center of Life Sciences Skolkovo Institute of Science and Technology;

Center of Life Sciences Skolkovo Institute of Science and Technology;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
ribosome; methylation; antibiotics; macrolides; aminoglycosides;

机译：核糖体;甲基化;抗生素;大啰染;氨基糖苷;

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1. Effective Antibiotic Stewardship Program: Controlling Antibiotic Resistance and Optimizing Drug Use in Ahmadi Hospital [J] . Saud M. Alajmi, Wadha N. Almarri 分析科学方法和仪器期刊（英文） . 2020,第001期
2. Influence of hydraulic retention time on behavior of antibiotics and antibiotic resistance genes in aerobic granular reactor treating biogas slurry [J] . Jie Liao1, Chaoxiang Liu2, Lin Liu123, 中国环境科学与工程前沿：英文版 . 2019,第003期
3. A structural basis for the antibiotic resistance conferred by an N1-methylation of A1408 in 16S rRNA [J] . Jiro Kondo, Fumika Baba, Mai Koganei, Nucleic acids research . 2017,第21期

机译：16S rRNA中A1408的N1-甲基化赋予抗生素抗性的结构基础
4. A structural basis for the antibiotic resistance conferred by an N1-methylation of A1408 in 16S rRNA [J] . Kanazawa Hiroki, Baba Fumika, Koganei Mai, Nucleic Acids Research . 2017,第21期

机译：A1408在16S rRNA中的N1-甲基化赋予抗生素抗性的结构基础
5. Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases [J] . Gordana Maravi?-Vlahovi?ek, J. Sivaraman, Janusz M. Bujnicki, Nucleic acids research . 2010,第12期

机译：抗生素生产商的氨基糖苷抗性甲基转移酶Sgm在16S rRNA中甲基化G1405的结构基础：m7G甲基转移酶中的多个活性位点
6. Identifying Possible rRNA Modifications That Cause Antibiotic Resistance [C] . Rebecca Rohlfs, Patrick A Limbach ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：确定可能导致抗生素抗性的可能rRNA修饰
7. Investigations into Streptomyces azureus thiostrepton-resistance rRNA methyltransferase and its cognate antibiotic [D] . Hang, Pei Chun 2009

机译：天青链霉菌抗硫链球菌rRNA甲基转移酶及其相关抗生素的研究
8. A structural basis for the antibiotic resistance conferred by an N1-methylation of A1408 in 16S rRNA [O] . Hiroki Kanazawa, Fumika Baba, Mai Koganei, 2017

机译：16S rRNA中A1408的N1-甲基化赋予抗生素抗性的结构基础
9. Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases [O] . Husain, Nilofer, Tkaczuk, Karolina L., Tulsidas, Shenoy Rajesh, 2010

机译：抗生素生产者的氨基糖苷抗性甲基转移酶Sgm在16S rRNA中甲基化G1405的结构基础：m7G甲基转移酶中多种活性位点
10. Antibiotic Resistance In Neisseria Gonorrhoeae: Impact Of Ceftriaxone Resistance On Microbial Fitness And Potential Of Resistance Determinants To Spread During Mixed Infection. [R] . Vincent, L. R. 2016

机译：淋病奈瑟菌的抗生素耐药性：头孢曲松耐药性对微生物适应性的影响以及在混合感染期间传播的抗性决定因素的潜力。

rRNA Methylation and Antibiotic Resistance

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