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首页> 外文期刊>Biomaterials Science >Nuclear delivery of dual anti-cancer drugs by molecular self-assembly
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Nuclear delivery of dual anti-cancer drugs by molecular self-assembly

机译：通过分子自组装核递送双抗癌药物

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摘要

Nanomedicines generally suffer from poor accumulation in tumor cells, low anti-tumor efficacy, and drug resistance. In order to address these problems, we introduced a novel nanomedicine based on dual anti-cancer drugs, which showed good cell nuclear accumulation properties. The novel nanomedicine consisted of three components: (1) dual anti-cancer drugs, 10-hydroxycamptothecin (HCPT) and chlorambucil (CRB), whose targets are located in the cell nucleus, (2) a nuclear localizing dodecapeptide, PMI peptide (TSFAEYWNLLSP), which could activate p53 by binding with MDM2 and MDMX located in the cell nucleus, and (3) an efficient self-assembling tripeptide FFY. Our nanomedicine exhibited enhanced cellular uptake and nuclear accumulation properties, thus achieving an excellent anti-cancer capacity both in vitro and in vivo. Our study will provide an inspiration for the development of novel multifunctional nanomaterials for cancer diagnosis and therapy.
机译：纳米美洲胺通常患有肿瘤细胞的差，抗肿瘤效果低，耐药性低。 为了解决这些问题，我们介绍了一种基于双抗癌药物的新型纳米胺，其显示出良好的细胞核积累性能。 新型纳米胺由三种组分组成：（1）双抗癌药物，10-羟基孢菌素（HCPT）和氯镁（CRB），其靶位于细胞核中，（2）核定位十二肽，PMI肽（TSFAEYWNLLSP ），其可以通过与位于细胞核中的MDM2和MDMX结合来激活P53，并且（3）高效的自组装三肽FFY。 我们的纳米胺发表具有增强的蜂窝摄取和核累积性能，从而在体外和体内实现了优异的抗癌能力。 我们的研究将为癌症诊断和治疗的新型多功能纳米材料开发提供灵感。

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  • 来源
    《Biomaterials Science》 |2021年第1期|共8页
  • 作者

    Wu Jindao; Ding Wenzhou; Han Guoyong; You Wei; Gao Wen; Shen Hongbing; Tang Jinhai; Tang Qiyun; Wang Xuehao;

  • 作者单位

    Nanjing Med Univ Affiliated Hosp 1 Dept Geriatr Digest Key Lab Liver Transplantat Chinese Acad Med Sci Hepatobiliary Ctr Dept Breast Surg Dept Oncol Nanjing Jiangsu Peoples R China;

    Nanjing Med Univ Affiliated Hosp 1 Dept Geriatr Digest Key Lab Liver Transplantat Chinese Acad Med Sci Hepatobiliary Ctr Dept Breast Surg Dept Oncol Nanjing Jiangsu Peoples R China;

    Nanjing Med Univ Affiliated Hosp 1 Dept Geriatr Digest Key Lab Liver Transplantat Chinese Acad Med Sci Hepatobiliary Ctr Dept Breast Surg Dept Oncol Nanjing Jiangsu Peoples R China;

    Nanjing Med Univ Affiliated Hosp 1 Dept Geriatr Digest Key Lab Liver Transplantat Chinese Acad Med Sci Hepatobiliary Ctr Dept Breast Surg Dept Oncol Nanjing Jiangsu Peoples R China;

    Nanjing Med Univ Affiliated Hosp 1 Dept Geriatr Digest Key Lab Liver Transplantat Chinese Acad Med Sci Hepatobiliary Ctr Dept Breast Surg Dept Oncol Nanjing Jiangsu Peoples R China;

    Nanjing Med Univ NHC Key Lab Living Donor Liver Transplantat Jiangsu Key Lab Canc Biomarkers Prevent &

    Treatme Collaborat Innovat Ctr Canc Personalized Med Sch Nanjing Jiangsu Peoples R China;

    Nanjing Med Univ Affiliated Hosp 1 Dept Geriatr Digest Key Lab Liver Transplantat Chinese Acad Med Sci Hepatobiliary Ctr Dept Breast Surg Dept Oncol Nanjing Jiangsu Peoples R China;

    Nanjing Med Univ Affiliated Hosp 1 Dept Geriatr Digest Key Lab Liver Transplantat Chinese Acad Med Sci Hepatobiliary Ctr Dept Breast Surg Dept Oncol Nanjing Jiangsu Peoples R China;

    Nanjing Med Univ Affiliated Hosp 1 Dept Geriatr Digest Key Lab Liver Transplantat Chinese Acad Med Sci Hepatobiliary Ctr Dept Breast Surg Dept Oncol Nanjing Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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