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首页> 外文期刊>Biomaterials Science >A near-infrared light-excitable immunomodulating nano-photosensitizer for effective photoimmunotherapy
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A near-infrared light-excitable immunomodulating nano-photosensitizer for effective photoimmunotherapy

机译：近红外光激发免疫调节纳米光敏剂，用于有效的光疗法

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摘要

Photodynamic therapy has great potential for tumor ablation and the activation of antitumor immune responses. However, its overall therapeutic efficiency is often limited by the immunosuppressive tumor microenvironment. We developed a near-infrared light-excitable immunomodulating nano-photosensitizer (NeINP) that can improve reactive oxygen species production and regulate the immunosuppressive TME to improve photoimmunotherapy. The NeINP is composed of a photosensitive core and a pH-responsive polymer shell, which allows for NeINP loading and delivery of small-molecular immunomodulators to tumor sites for regulation of the immunosuppressive TME and effective photoimmunotherapy. Through the co-delivery of celecoxib and the NIR-triggered photodynamic core to tumors, the NeINP was shown to regulate the immunosuppressive TME and enhance antitumor immunity, leading to the elimination of residual tumor and reduction of metastasis and recurrence. The NeINP can be optimized to co-deliver other immunomodulators, and thus has potential as a universal platform for efficient, precise photoimmunotherapy.
机译：光动力疗法具有巨大的肿瘤消融和抗肿瘤免疫反应的激活。然而，其整体治疗效率通常受免疫抑制肿瘤微环境的限制。我们开发了一种近红外光激发免疫调节纳米光敏剂（NeinP），可以改善活性氧物种生产并调节免疫抑制TME以改善光疗法。 NeinP由光敏核和pH-响应聚合物壳组成，其允许NeinP装载和分娩的小分子免疫调节剂以调节免疫抑制TME和有效的光疗法。通过Celecoxib的共同递送和触发的光动力学核心到肿瘤，显示NeinP调节免疫抑制TME并增强抗肿瘤免疫力，从而消除残留肿瘤和转移和复发的降低。 NeinP可以优化以共同提供其他免疫调节器，因此具有潜在的高效，精确的光疗法平台。

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