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A reduced polydopamine nanoparticle-coupled sprayable PEG hydrogel adhesive with antiinfection activity for rapid wound sealing

机译：一种可减少的多碳双胺纳米粒子偶联的可喷涂PEG水凝胶粘合剂，具有快速伤口密封的抗抗凝固活性

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摘要

There is a growing demand to develop sprayable hydrogel adhesives with rapid-forming and antibacterial abilities to instantly seal open wounds and combat pathogen infection. Herein, we propose to design a polydopamine nanoparticle (PDA NP) coupled PEG hydrogel that can quickly solidify via an amidation reaction after spraying as well as tightly binding PDA NPs to deliver reactive oxygen species (ROS) and induce a photothermal effect for bactericidal activity, and provide a hydrophilic surface for antifouling activity. The molecular structure of the 4-arm-PEG-NHS precursor was regulated to increase its reactivity with 4-arm-PEG-NH_2, which thus shortened the gelation time of the PEG adhesive to 1 s to allow a fast solidification after being sprayed. The PEG-NHS precursor also provided covalent binding with tissue and PDA NPs. The reduced PDA NPs have redox activity to convey electrons to oxygen to generate ROS (H_2O_2), thus endowing the hydrogel with ROS dependent antibacterial ability. Moreover, NIR irradiation can accelerate the ROS release because of the photothermal effect of PDA NPs. In vitro tests demonstrated that H_2O_2 and the NIR-photothermal effect synergistically induced a fast bacterial killing, and an in vivo anti-infection test also proved the effectiveness of PEG-PDA. The sprayable PEG-PDA hydrogel adhesive, with rapid-forming performance and a dual bactericidal mechanism, may be promising for sealing large-scale and acute wound sites or invisible bleeding sites, and protect them from pathogen infection.
机译：随着快速成型和抗菌能力开发可喷雾的水凝胶粘合剂的需求不断增长，以瞬间密封开放的伤口和战斗病原体感染。在此，我们提出设计聚德莫胺纳米颗粒（PDA NP）偶联的PEG水凝胶，其可以在喷涂后通过酰胺化反应以及紧密结合PDA NP来递送反应性氧物质（ROS）并诱导杀菌活性的光热效应，并提供用于防污活性的亲水性表面。调节4臂-PEG-NHS前体的分子结构以增加与4臂-PEG-NH_2的反应性，从而将PEG粘合剂的凝胶化时间缩短至1S以允许在喷射后进行快速凝固。 PEG-NHS前体还提供与组织和PDA NPS的共价结合。减少的PDA NPS具有氧化还原活性以将电子传送到氧气以产生ROS（H_2O_2），从而赋予水凝胶与ROS依赖性抗菌能力。此外，由于PDA NP的光热效应，NIR辐射可以加速ROS释放。体外测试证明H_2O_2和NIR-光热效应协同诱导快速细菌杀伤，并且体内抗感染试验也证明了PEG-PDA的有效性。具有快速形成性能和双杀菌机制的可喷涂的PEG-PDA水凝胶粘合剂可能是对密封大规模和急性缠绕位点或看不见的出血位点的承诺，并保护它们免受病原体感染。

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  • 来源
    《Biomaterials Science》 |2020年第24期|共11页
  • 作者

    Junjie Sun; Haoqi Tan; Huan Liu; Dawei Jin; Meng Yin; Haodong Lin; Xue Qu; Changsheng Liu;

  • 作者单位

    Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry School of material science and engineering East China University of Science and Technology Shanghai 200237 China;

    Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry School of material science and engineering East China University of Science and Technology Shanghai 200237 China;

    Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry School of material science and engineering East China University of Science and Technology Shanghai 200237 China;

    Department of Cardiothoracic Surgery Shanghai Children's Medical Center School of Medicine Shanghai Jiao Tong University 1678 Dong Fang Road Shanghai 200127 China;

    Department of Cardiothoracic Surgery Shanghai Children's Medical Center School of Medicine Shanghai Jiao Tong University 1678 Dong Fang Road Shanghai 200127 China;

    Department of Orthopedic Surgery Shanghai General Hospital Shanghai Jiaotong University School of Medicine Shanghai 200080 China;

    Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry School of material science and engineering East China University of Science and Technology Shanghai 200237 China;

    Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry School of material science and engineering East China University of Science and Technology Shanghai 200237 China;

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