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首页> 外文期刊>Biomaterials Science >Optimizing microenvironment by integrating negative pressure and exogenous electric fields via a flexible porous conductive dressing to accelerate wound healing
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Optimizing microenvironment by integrating negative pressure and exogenous electric fields via a flexible porous conductive dressing to accelerate wound healing

机译：通过柔性多孔导电敷料整合负压和外源电场优化微环境，以加速伤口愈合

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摘要

Wound healing is a complex and sequential biological process that involves multiple stages. Current treatments for nonhealing or chronic wounds are unsatisfactory as they exert a single effect on one specific activity. Herein, we constructed a silver nanowire (AgNW)-based, three-dimensional (3D), porous foam dressing that is flexible and conductive. This conductive foam dressing was composed of AgNWs modified with a stable hydrophobic coating and porous polyurethane (PU), providing a skeleton to support the 3D conductive networks. The AgNWs-PU foam dressing exhibited favorable biocompatibility, outstanding electrical properties, excellent bending-compression durability, and long-term stability under wet conditions, making it suitable for wound treatment. Via the conductive foam dressing, negative pressure and exogenous wound directional electric fields (EFs) could be integrated for simultaneous implementation, and the artificial jointly constructed microenvironment promoted wound healing in a system. This novel "all-in-one" device presented intrinsic multifunctionality, including the drainage of pus and necrotic tissue, mitigation of inflammation, promotion of cell proliferation, direction of keratinocyte migration, and induction of angiogenesis. An immunohistochemical assay and western blot analysis illustrated that the angiogenesis and cell proliferation pathways in the tissue were significantly activated when this novel therapy was adopted. More importantly, the practical performance of this "all-in-one" device was demonstrated by assessment of full-thickness defect wounds in model pigs. Comparing the percentage of residual wound area after administration of traditional treatment (25.82 +/- 3.52%) and the novel treatment (3.07 +/- 1.23%) demonstrated the promising applications of this novel treatment in clinical wound healing.
机译：伤口愈合是一种复杂和连续的生物过程，涉及多个阶段。当时对非热性或慢性伤口的目前的治疗是不令人满意的，因为它们对一种特异性活性产生单一效果。在此，我们构建了基于银纳米线（AgNW）的三维（3D），多孔泡沫敷料是柔性的和导电的。该导电泡沫敷料由用稳定的疏水涂层和多孔聚氨酯（PU）改性的AgNW组成，提供骨架以支撑3D导电网络。 Agnws-Pu泡沫敷料在潮湿条件下表现出良好的生物相容性，优异的电性能，优异的弯曲压缩耐久性，以及长期稳定性，使其适用于伤口处理。通过导电泡沫敷料，负压和外源缠绕方向电场（EFS）可以集成用于同时实施，并且人工共同构建的微环境在系统中促进伤口愈合。这种新的“一体化”装置呈现了内在的多功能性，包括脓液和坏死组织的排水，减轻炎症，促进细胞增殖，角蛋白细胞迁移方向，以及血管生成的诱导。免疫组织化学测定和蛋白质印迹分析表明，当采用这种新疗法时，组织中的血管生成和细胞增殖途径被显着激活。更重要的是，通过评估模型猪中的全厚度缺陷伤口来证明了这种“一体化”装置的实际性能。比较传统治疗后残留伤口面积的百分比（25.82 +/- 3.52％）和新型治疗（3.07 +/- 1.23％）证明了这种新型治疗在临床伤口愈合中的有前途的应用。

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  • 来源
    《Biomaterials Science》 |2021年第1期|共14页
  • 作者

    Chen Ying; Liang Yi; Liu Jie; Yang Jinrui; Jia Naixin; Zhu Chuhong; Zhang Jiaping;

  • 作者单位

    Army Med Univ Southwest Hosp State Key Lab Trauma Burns &

    Combined Injury Dept Plast Surg Third Mil Med Univ Chongqing 400038 Peoples R China;

    Army Med Univ Southwest Hosp State Key Lab Trauma Burns &

    Combined Injury Dept Plast Surg Third Mil Med Univ Chongqing 400038 Peoples R China;

    Army Med Univ Southwest Hosp State Key Lab Trauma Burns &

    Combined Injury Dept Plast Surg Third Mil Med Univ Chongqing 400038 Peoples R China;

    Army Med Univ Southwest Hosp State Key Lab Trauma Burns &

    Combined Injury Dept Plast Surg Third Mil Med Univ Chongqing 400038 Peoples R China;

    Army Med Univ Southwest Hosp State Key Lab Trauma Burns &

    Combined Injury Dept Plast Surg Third Mil Med Univ Chongqing 400038 Peoples R China;

    Army Med Univ Third Mil Med Univ State Key Lab Trauma Burn &

    Combined Injury Dept Anat Dept Plast Surg Southwest Hosp Key Lab Chongqing 400038 Peoples R China;

    Army Med Univ Southwest Hosp State Key Lab Trauma Burns &

    Combined Injury Dept Plast Surg Third Mil Med Univ Chongqing 400038 Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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