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首页> 外文期刊>Biomaterials Science >Mesoporous silica integrated with Fe_3O_4 and palmitoyl ascorbate as a new nano-Fenton reactor for amplified tumor oxidation therapy
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Mesoporous silica integrated with Fe_3O_4 and palmitoyl ascorbate as a new nano-Fenton reactor for amplified tumor oxidation therapy

机译：中孔二氧化硅与Fe_3O_4和Palmitoyl集成，抗坏血酸作为扩增肿瘤氧化治疗的新型纳米芬顿反应器

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摘要

Co-delivery of H_2O_2-generating agent and catalyst via a nano-Fenton reactor to the tumor acidic microenvironment for amplified tumor oxidation therapy has been widely studied. However, high side effects and low efficiency remain the limitations of the design and development of this process. Herein, a new nano-Fenton reactor in which mesoporous silica is integrated with Fe_3O_4 and palmitoyl ascorbate (Fe_3O_4@SiO_2-PA) was designed, with the product exhibiting good dispersion, stability, uniformity and consistent spectral characteristics. The results show that Fe_3O_4@mSiO_2-PA successfully enters cancer cells, significantly inhibits HeLa cells and 3D tumor spheroid growth in vitro via the induction of apoptosis. Meanwhile, Fe_3O_4@mSiO_2-PA administration in vivo markedly suppresses HeLa tumor xenografts growth via the induction of apoptosis, followed by caspase-3 activation and cytochrome C release. Further investigation revealed that Fe_3O_4@mSiO_2-PA causes enhanced production of reactive oxygen species (ROS), which subsequently triggers DNA damage and causes dysfunction of the MAPK and PI3K/AKT pathways. Importantly, Fe_3O_4@mSiO_2-PA shows few side effects and good biocompatibility in vivo. Taken together, these results suggest that Fe_3O_4@mSiO_2-PA inhibits HeLa cell growth in vitro and in vivo by triggering enhanced oxidative damage and regulating multiple signal pathways. Our findings validate the rational design that mesoporous silica integrated with Fe_3O_4 and palmitoyl ascorbate can act as a new nano-Fenton reactor for amplified tumor oxidation therapy.
机译：通过纳米Fenton反应器将H_2O_2产生剂和催化剂的共同递送到肿瘤酸性微环境，得到扩增的肿瘤氧化治疗。然而，高副作用和低效率仍然是该过程的设计和发展的局限性。这里，设计了一种新的纳米芬华反应器，其中介孔二氧化硅与Fe_3O_4和棕榈酰抗坏血酸（Fe_3O_4 / 2-PA）设计，具有良好的分散体，稳定性，均匀性和一致的光谱特性。结果表明，Fe_3O_4 @ MSIO_2-PA成功进入癌细胞，通过诱导细胞凋亡，显着抑制Hela细胞和3D肿瘤球状生长。同时，FE_3O_4 @ MSIO_2-PA管理通过诱导细胞凋亡，随后是Caspase-3活化和细胞色素C释放，MSIO_2-PA @ MSIO_2-PA管理显着抑制Hela肿瘤异种移植物生长。进一步的研究表明，Fe_3O_4 @ MSIO_2-PA会导致增强的活性氧物质（ROS）产生，随后触发DNA损伤并导致MAPK和PI3K / AKT途径的功能障碍。重要的是，FE_3O_4 @ MSIO_2-PA在体内显示少量副作用和良好的生物相容性。总之，这些结果表明Fe_3O_4 @ MSIO_2-PA通过触发增强的氧化损伤和调节多个信号途径来抑制体外和体内的HELA细胞生长。我们的研究结果验证了与Fe_3O_4和Palmitoyl集成的中孔二氧化硅和Palmitoyl抗坏血酸的合理设计可作为扩增肿瘤氧化治疗的新纳米芬顿反应器。

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  • 来源
    《Biomaterials Science》 |2020年第24期|共12页
  • 作者

    Yu Sun; Zekun Wang; Pu Zhang; Jingyuan Wang; Ying Chen; Chenyang Yin; Weiyun Wang; Cundong Fan; Dongdong Sun;

  • 作者单位

    School of Life Sciences Anhui Agricultural University Hefei 230036 China;

    School of Life Sciences Anhui Agricultural University Hefei 230036 China;

    Department of Cardiovascular Medicine Taian City Central Hospital Taian Shandong 271000 China;

    School of Life Sciences Anhui Agricultural University Hefei 230036 China;

    School of Life Sciences Anhui Agricultural University Hefei 230036 China;

    School of Life Sciences Anhui Agricultural University Hefei 230036 China;

    School of Life Sciences Anhui Agricultural University Hefei 230036 China;

    Key Lab of Cerebral Microcirculation in Universities of Shandong;

    Second Affiliated Hospital Shandong First Medical University &

    Shandong Academy of Medical Sciences Taian Shandong 271000 China;

    School of Life Sciences Anhui Agricultural University Hefei 230036 China;

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  • 中图分类 计量学;
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