A multi-effective and long-acting immunotherapy through one single hydrogel based injection

Wang Manyu; Cheng Xinyan; Luo Lin; Liu Yu; Cao Fei; Zhao Siyu; Peng Haichuan; Hong Can; Jin Liguo; Deng Libin; Xin Hongbo; Wang Xiaolei

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A multi-effective and long-acting immunotherapy through one single hydrogel based injection

机译：通过一种基于一个基于水凝胶的注射剂进行多功能和长效的免疫疗法

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A dual-effective (photothermal and immune) therapy employing gold nanorods (AuNRs) with a drug (two macrophage migration inhibitory factor (MIF) inhibitors) sustained release hydrogel was designed in this paper. The subsequent cellular and animal studies demonstrated that the proposed therapy can not only inhibit the proliferation, migration, and recurrence of cancer cells, but also improve the immune function (increase the infiltration of CD8(+) killer T cells in tumors) without the traditional multiple injections of expensive immune drugs.

机译：本文设计了用药物（两种巨噬细胞迁移抑制因子（MIF）抑制剂）持续释放水凝胶的双效（光热和免疫）治疗。随后的细胞和动物研究表明，所提出的治疗不仅可以抑制癌细胞的增殖，迁移和复发，还可以改善免疫功能（增加肿瘤中CD8（+）杀伤T细胞的渗透）而没有传统的多次注射昂贵的免疫药物。

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来源
《Biomaterials Science》 |2021年第4期|共7页
作者
Wang Manyu; Cheng Xinyan; Luo Lin; Liu Yu; Cao Fei; Zhao Siyu; Peng Haichuan; Hong Can; Jin Liguo; Deng Libin; Xin Hongbo; Wang Xiaolei;
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作者单位

Nanchang Univ Inst Translat Med Natl Engn Res Ctr Bioengn Drugs &

Technol Nanchang 330088 Jiangxi Peoples R China;

Nanchang Univ Coll Chem Nanchang 330088 Jiangxi Peoples R China;

Nanchang Univ Inst Translat Med Natl Engn Res Ctr Bioengn Drugs &

Technol Nanchang 330088 Jiangxi Peoples R China;

Nanchang Univ Inst Translat Med Natl Engn Res Ctr Bioengn Drugs &

Technol Nanchang 330088 Jiangxi Peoples R China;

Nanchang Univ Inst Translat Med Natl Engn Res Ctr Bioengn Drugs &

Technol Nanchang 330088 Jiangxi Peoples R China;

Nanchang Univ Inst Translat Med Natl Engn Res Ctr Bioengn Drugs &

Technol Nanchang 330088 Jiangxi Peoples R China;

Nanchang Univ Inst Translat Med Natl Engn Res Ctr Bioengn Drugs &

Technol Nanchang 330088 Jiangxi Peoples R China;

Nanchang Univ Inst Translat Med Natl Engn Res Ctr Bioengn Drugs &

Technol Nanchang 330088 Jiangxi Peoples R China;

Nanchang Univ Coll Chem Nanchang 330088 Jiangxi Peoples R China;

Nanchang Univ Inst Translat Med Natl Engn Res Ctr Bioengn Drugs &

Technol Nanchang 330088 Jiangxi Peoples R China;

Nanchang Univ Inst Translat Med Natl Engn Res Ctr Bioengn Drugs &

Technol Nanchang 330088 Jiangxi Peoples R China;

Nanchang Univ Inst Translat Med Natl Engn Res Ctr Bioengn Drugs &

Technol Nanchang 330088 Jiangxi Peoples R China;

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正文语种 eng
中图分类分子生物学;
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1. Single Phase-to-Ground Fault Line Identification and Section Location Method for Non-Effectively Grounded Distribution Systems Based on Signal Injection [J] . 潘贞存, 王成山, 丛伟, 天津大学学报：英文版 . 2008,第002期
2. Single Phase-to-Ground Fault Line Identification and Section Location Method for Non-Effectively Grounded Distribution Systems Based on Signal Injection [J] . PAN Zhencun, WANG Chengshan, CONG Wei, 天津大学学报（英文版） . 2008,第002期
3. Intra-Articular injection of acid-sensitive stearoxyl-ketal-dexamethasone microcrystals for long-acting arthritis therapy [J] . Yang Xu, Ziqi Chen, Zunkai Xu, 亚洲药物制剂科学(英文) . 2021,第002期
4. Polypseudorotaxane and polydopamine linkage-based hyaluronic acid hydrogel network with a single syringe injection for sustained drug delivery [J] . Hwang ChaeRim, Lee Song Yi, Kim Han-Jun, Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides . 2021,第1期

机译：基于息氨酸和聚二氨基键的透明质酸水凝胶网络，具有单个注射器注射器，用于持续的药物递送
5. Pharmacokinetics of a Single Intramuscular Injection of Long-Acting Ceftiofur Crystalline-Free Acid in Cattle Egrets (Bubulcus ibis) [J] . Waldoch Jennifer A., Cox Sherry K., Armstrong Douglas L. Journal of Avian Medicine and Surgery . 2017,第4期

机译：牛白鹭肌内注射长效性Ceftofur结晶酸的药代动力学（Bumulcus Ibis）
6. PM499. Improvement of cognitive function before and after 2-year treatment with long-acting injection (LAI) of antipsychotics evaluated by NIRS using single word-induced hemoglobin variation as an index [J] . The international journal of neuropsychopharmacology . 2016,第Suppla1期

机译：PM499。以单词诱发的血红蛋白变异为指标，通过NIRS评估抗精神病药物长效注射（LAI）治疗2年前后的认知功能改善
7. Combining software-implemented and simulation-based fault injection into a single fault injection method [C] . Guthoff, J., Sieh, Fault-Tolerant Computing, 1995. FTCS-25. Digest of Papers., Twenty-Fifth International Symposium on . 1995

机译：将软件实现的和基于仿真的故障注入结合到单个故障注入方法中
8. Development and Evaluation of a Web-Based Educational Toolkit on the Knowledge, Attitudes, and Practice of Psychiatric Prescribers Regarding Long-Acting Injectable Antipsychotics [D] . Lewis, Lisa. 2020

机译：关于长效可注射抗精神病学的知识，态度和精神公务员的知识，态度和实践的发展与评估。
9. PM499. Improvement of cognitive function before and after 2-year treatment with long-acting injection (LAI) of antipsychotics evaluated by NIRS using single word-induced hemoglobin variation as an index [O] . Yoshihisa Shoji, Masayuki Inoue, Youhei Ishii, 2016

机译：PM499。以单词诱导的血红蛋白变异为指标通过NIRS评估长效注射（LAI）抗精神病药物2年治疗前后的认知功能改善
10. Long-Acting Profile of 4 Drugs in 1 Anti-HIV Nanosuspension in Nonhuman Primates for 5 Weeks After a Single Subcutaneous Injection [O] . Lisa A. McConnachie, Loren M. Kinman, Josefin Koehn, 2018

机译：在单一皮下注射后，在非人的1次抗HIV纳米术中的4种药物的长效型材。一次皮下注射后5周
11. Assessment of Pellet Injection for NET. Pt. 1 and 2. Pt. 1: Penetration Depth Calculations for Single Pellets on the Basis of Available Ablation Models. Pt. 2: Pellet Sizes and Velocities Required for Central Fuelling Based on Available Ablation Models: Feasibility Considerations [R] . Lengyel, L. L. 1984

机译：NET的颗粒注射评估。铂。 1和2. pt。 1：基于可用消融模型的单颗粒的穿透深度计算。铂。 2：基于可用消融模型的中央加油所需的颗粒尺寸和速度：可行性考虑因素

A multi-effective and long-acting immunotherapy through one single hydrogel based injection

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