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The design criteria and therapeutic strategy of functional scaffolds for spinal cord injury repair

机译：脊髓损伤修复功能支架的设计标准和治疗策略

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摘要

Spinal cord injury (SCI) remains a therapeutic challenge in clinic. Current drug and cell therapeutics have obtained significant efficacy but are still in the early stages for complete neural and functional recovery. In the past few decades, functional scaffolds (FSs) have been rapidly developed to bridge the lesion and provide a framework for tissue regeneration in SCI repair. Moreover, a FS can act as an adjuvant for locally delivering drugs in the lesion with a designed drug release profile, and supplying a biomimetic environment for implanted cells. In this review, the design criteria of FSs for SCI treatment are summarized according to their biocompatibility, mechanical properties, morphology, architecture, and biodegradability. Subsequently, FSs designed for SCI repair in the scope of drug delivery, cell implantation and combination therapy are introduced, respectively. And how a FS promotes their therapeutic efficacy is analyzed. Finally, the challenges, perspectives, and potential of FSs for SCI treatment are discussed. Hopefully, this review may inspire the future development of potent FSs to facilitate SCI repair in clinic.
机译：脊髓损伤（SCI）仍然是诊所的治疗挑战。目前的药物和细胞治疗剂已经获得了显着的功效，但仍处于完全神经和功能恢复的早期阶段。在过去的几十年里，功能性脚手架（FSS）已迅速发展以弥合病变，并为SCI修复中的组织再生提供框架。此外，FS可以用作局部递送病变中药物的佐剂，并为设计的药物释放曲线提供型药物，并为植入细胞提供仿生环境。在本文中，根据其生物相容性，机械性能，形态，架构和生物降解性来概述了SCI处理的FSS的设计标准。随后，分别引入了用于药物递送范围，细胞植入和联合治疗的SCI修复的FSS。分析了FS如何促进其治疗效果。最后，讨论了FSS对SCI治疗的挑战，观点和潜力。希望这篇评论可能会激发有利的FSS的未来发展，以促进诊所的SCI修复。

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  • 来源
    《Biomaterials Science》 |2021年第13期|共16页
  • 作者

    Cao Jian; Wu Jiahe; Mu Jiafu; Feng Shiqing; Gao Jianqing;

  • 作者单位

    Zhejiang Univ Coll Pharmaceut Sci Inst Pharmaceut Zhejiang Prov Key Lab Anticanc Drug Res Hangzhou 310058 Peoples R China;

    Zhejiang Univ Coll Pharmaceut Sci Inst Pharmaceut Zhejiang Prov Key Lab Anticanc Drug Res Hangzhou 310058 Peoples R China;

    Zhejiang Univ Coll Pharmaceut Sci Inst Pharmaceut Zhejiang Prov Key Lab Anticanc Drug Res Hangzhou 310058 Peoples R China;

    Tianjin Med Univ Gen Hosp Dept Orthoped Tianjin 300052 Peoples R China;

    Zhejiang Univ Coll Pharmaceut Sci Inst Pharmaceut Zhejiang Prov Key Lab Anticanc Drug Res Hangzhou 310058 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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